Luke J Mortensen
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Explore the profile of Luke J Mortensen including associated specialties, affiliations and a list of published articles.
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57
Citations
1582
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Recent Articles
1.
Zheng T, Pendleton E, Barrow R, Maslesa A, Kner P, Mortensen L
Biomed Opt Express
. 2024 Dec;
15(12):6940-6956.
PMID: 39679410
Polarization-resolved second harmonic generation (pSHG) is a label-free method that has been used in a range of tissue types to describe collagen orientation. In this work, we develop pSHG analysis...
2.
Turner T, Pittman F, Zhang H, Hymel L, Zheng T, Behara M, et al.
bioRxiv
. 2024 Sep;
PMID: 39314313
Severe tissue loss resulting from extremity trauma, such as volumetric muscle loss (VML), poses significant clinical challenges for both general and military populations. VML disrupts the endogenous tissue repair mechanisms,...
3.
Nath P, Liversage A, Mortensen L, Ray A
ACS Appl Mater Interfaces
. 2024 Aug;
16(35):46035-46043.
PMID: 39167710
Multiphoton fluorescence microscopy is a powerful tool for imaging and exploring biological tissue at subcellular spatial resolution while minimizing photobleaching and autofluorescence. For optimal performance in multiphoton microscopy, materials exhibiting...
4.
Priyadarshani P, Grouw A, Liversage A, Rui K, Nikitina A, Tehrani K, et al.
Cell Rep
. 2024 Aug;
43(8):114579.
PMID: 39153198
Mesenchymal stem/stromal cell (MSC) therapies have had limited success so far in clinical trials due in part to heterogeneity in immune-responsive phenotypes. Therefore, techniques to characterize these properties of MSCs...
5.
Baumann C, Zhang X, Kandasamy M, Mei X, Chen S, Tehrani K, et al.
Commun Biol
. 2023 Dec;
6(1):1258.
PMID: 38086992
The mechanisms leading to changes in mesoscale chromatin organization during cellular aging are unknown. Here, we used transcriptional activator-like effectors, RNA-seq and superresolution analysis to determine the effects of genotoxic...
6.
Pendleton E, Nichenko A, Mcfaline-Figueroa J, Raymond-Pope C, Schifino A, Pigg T, et al.
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958888
Hypophosphatasia (HPP) is a rare metabolic bone disorder characterized by low levels of tissue non-specific alkaline phosphatase (TNAP) that causes under-mineralization of the bone, leading to bone deformity and fractures....
7.
Zheng T, Liversage A, Tehrani K, Call J, Kner P, Mortensen L
Front Neuroimaging
. 2023 Aug;
2:959601.
PMID: 37554651
Introduction: Mitochondria are extremely important organelles in the regulation of bone marrow and brain activity. However, live imaging of these subcellular features with high resolution in scattering tissues like brain...
8.
Hymel L, Anderson S, Turner T, York W, Zhang H, Liversage A, et al.
Commun Biol
. 2023 Jul;
6(1):749.
PMID: 37468760
Volumetric muscle loss (VML) results in permanent functional deficits and remains a substantial regenerative medicine challenge. A coordinated immune response is crucial for timely myofiber regeneration, however the immune response...
9.
Khan N, Diaz-Hernandez M, Chihab S, Priyadarshani P, Bhattaram P, Mortensen L, et al.
Elife
. 2023 Jan;
12.
PMID: 36715686
Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine. The iPSCs exhibit a preference for lineage differentiation to the donor cell type indicating the existence of memory...
10.
Nuzhdin D, Pendleton E, Munger E, Mortensen L, Brasselet S
J Microsc
. 2022 Dec;
291(1):57-72.
PMID: 36455264
Polarised nonlinear microscopy has been extensively developed to study molecular organisation in biological tissues, quantifying the response of nonlinear signals to a varying incident linear polarisation. Polarisation Second harmonic Generation...