Luke J Janssen
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Explore the profile of Luke J Janssen including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Lebeau P, Byun J, Platko K, Saliba P, Sguazzin M, MacDonald M, et al.
Nat Commun
. 2022 Feb;
13(1):770.
PMID: 35140212
Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here, we investigated the effect of CF on...
2.
Riccardi D, Ward J, Yarova P, Janssen L, Lee T, Ying S, et al.
Eur Respir J
. 2022 Jan;
60(2).
PMID: 35058244
In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the...
3.
Al-Mutairy E, Imtiaz F, Khalid M, Al Qattan S, Saleh S, Mahmoud L, et al.
Eur Respir J
. 2019 May;
54(1).
PMID: 31073086
Background: Pulmonary fibrosis is one of the leading indications for lung transplantation. The disease, which is of unknown aetiology, can be progressive, resulting in distortion of the extracellular matrix (ECM),...
4.
Mukherjee S, Sheng W, Michkov A, Sriarm K, Sun R, Dvorkin-Gheva A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2019 Feb;
316(5):L810-L821.
PMID: 30758990
We have shown that calcium (Ca) oscillations in human pulmonary fibroblasts (HPFs) contribute to profibrotic effects of transforming growth factor-β (TGF-β) and that disruption of these oscillations blunts features of...
5.
Rahman M, Sun R, Mukherjee S, Nilius B, Janssen L
Am J Respir Cell Mol Biol
. 2018 Feb;
59(1):87-95.
PMID: 29393654
We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient receptor potential, vanilloid-type, subtype 4)-channel agonists: 4αPDD (4α-phorbol-12,13-didecanoate) and GSK1016790A. However,...
6.
Mukherjee S, Sheng W, Sun R, Janssen L
Am J Physiol Lung Cell Mol Physiol
. 2017 Jan;
312(4):L510-L519.
PMID: 28130256
It is now clear that in addition to activating several complex kinase pathways (Smad, MAP kinase, PI3 kinase), TGFβ also acts by elevating cytosolic Ca concentration within human pulmonary fibroblasts....
7.
Rahman M, Mukherjee S, Sheng W, Nilius B, Janssen L
Am J Physiol Lung Cell Mol Physiol
. 2016 Feb;
310(7):L603-14.
PMID: 26851262
We have presented indirect evidence of a key role for voltage-dependent Ca(2+) currents in TGFβ-induced synthetic function in human pulmonary fibroblast (HPF), as well as in bleomycin-induced pulmonary fibrosis in...
8.
Hare D, Collins S, Mukherjee S, Loo Y, Gale Jr M, Janssen L, et al.
J Virol
. 2016 Jan;
90(6):3018-27.
PMID: 26719279
Unlabelled: The type I interferon (IFN) response is an important aspect of innate antiviral defense, and the transcription factor IRF3 plays an important role in its induction. Membrane perturbation during...
9.
Ahmadzai M, Small M, Sehmi R, Gauvreau G, Janssen L
Front Immunol
. 2015 Nov;
6:525.
PMID: 26539194
Eosinophil migration to the lung is primarily regulated by the eosinophil-selective family of eotaxin chemokines, which mobilize intracellular calcium (Ca(2+)) and orchestrate myriad changes in cell structure and function. Eosinophil...
10.
Janssen L, Gauvreau G, Killian K, OByrne P
Ann Am Thorac Soc
. 2015 Oct;
12(10):1589-91.
PMID: 26448357
No abstract available.