Luke Gammon
Overview
Explore the profile of Luke Gammon including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
671
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0
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Recent Articles
11.
Gemenetzidis E, Gammon L, Biddle A, Emich H, Mackenzie I
Oncotarget
. 2015 Nov;
6(41):43964-77.
PMID: 26540568
There is a significant amount of evidence to suggest that human tumors are driven and maintained by a sub-population of cells, known as cancer stem cells (CSC). In the case...
12.
Gammon L, Mackenzie I
J Oral Pathol Med
. 2015 May;
45(2):77-82.
PMID: 25952002
Evidence from a wide range of studies indicates that hypoxia and the resulting cellular changes that are induced by HIF-1α lead to transcriptional up-regulation of a diversity of genes that...
13.
Shigeishi H, Biddle A, Gammon L, Rodini C, Yamasaki M, Seino S, et al.
J Oral Pathol Med
. 2014 Aug;
44(3):201-7.
PMID: 25169655
Background: Cancer stem cells (CSCs) are involved in both tumourigenesis and in tumour recurrence after therapy. In head and neck squamous cell carcinoma (HNSCC), there are two biologically different CSC...
14.
Shigeishi H, Biddle A, Gammon L, Emich H, Rodini C, Gemenetzidis E, et al.
Stem Cells
. 2013 May;
31(10):2073-83.
PMID: 23649588
Cells sorted from head and neck cancers on the basis of their high expression of CD44 have high potency for tumor initiation. These cells are also involved in epithelial to...
15.
Gammon L, Biddle A, Heywood H, Johannessen A, Mackenzie I
PLoS One
. 2013 May;
8(4):e62493.
PMID: 23638097
The glycolytic response of hypoxic cells is primarily mediated by the hypoxia inducible factor alpha (HIF-1α) but even in the presence of abundant oxygen tumours typically show high rates of...
16.
Biddle A, Gammon L, Fazil B, Mackenzie I
PLoS One
. 2013 Feb;
8(2):e57314.
PMID: 23437366
CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high) cancer stem-like cell...
17.
Tsang S, Brown L, Gadmor H, Gammon L, Fortune F, Wheeler A, et al.
Exp Cell Res
. 2012 Jul;
318(18):2269-83.
PMID: 22796473
Desmoglein 3 (Dsg3), a member of the desmoglein sub-family, serves as an adhesion molecule in desmosomes. Our previous study showed that overexpression of human Dsg3 in several epithelial lines induces...
18.
Biddle A, Liang X, Gammon L, Fazil B, Harper L, Emich H, et al.
Cancer Res
. 2011 Jun;
71(15):5317-26.
PMID: 21685475
Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which causes many cancer deaths. Cancer stem cells (CSC) that maintain and initiate tumors have also been implicated...
19.
Gammon L, Biddle A, Fazil B, Harper L, Mackenzie I
J Oral Pathol Med
. 2010 Dec;
40(2):143-52.
PMID: 21138479
Increasing evidence indicates that cancer growth is driven by a sub-population of self-renewing cancer stem cells (CSCs) and that clinical problems of tumor recurrence after therapy may be related to...
20.
Harper L, Costea D, Gammon L, Fazil B, Biddle A, Mackenzie I
BMC Cancer
. 2010 Apr;
10:166.
PMID: 20426848
Background: Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment failure....