Luke Esposito
Overview
Explore the profile of Luke Esposito including associated specialties, affiliations and a list of published articles.
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24
Citations
1723
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Recent Articles
1.
Jin K, Yao Z, van Velthoven C, Kaplan E, Glattfelder K, Barlow S, et al.
Nature
. 2025 Jan;
638(8049):182-196.
PMID: 39743592
Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Mammalian brains consist of thousands of cell types, which may be...
2.
Gabitto M, Travaglini K, Rachleff V, Kaplan E, Long B, Ariza J, et al.
Nat Neurosci
. 2024 Oct;
27(12):2366-2383.
PMID: 39402379
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we...
3.
Hunker A, Wirthlin M, Gill G, Johansen N, Hooper M, Omstead V, et al.
bioRxiv
. 2024 Oct;
PMID: 39386678
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Best-in-class vectors were curated for accessing major striatal neuron populations including medium spiny neurons (MSNs),...
4.
Ben-Simon Y, Hooper M, Narayan S, Daigle T, Dwivedi D, Way S, et al.
bioRxiv
. 2024 Jun;
PMID: 38915722
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential...
5.
Sorensen S, Gouwens N, Wang Y, Mallory M, Budzillo A, Dalley R, et al.
bioRxiv
. 2024 Jan;
PMID: 38168270
The mammalian brain is composed of diverse neuron types that play different functional roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of transcriptomically-defined cell types,...
6.
Jin K, Yao Z, van Velthoven C, Kaplan E, Glattfelder K, Barlow S, et al.
bioRxiv
. 2024 Jan;
PMID: 38168182
Biological aging can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Aging is a complex and dynamic process which influences distinct cell...
7.
Yao Z, van Velthoven C, Kunst M, Zhang M, McMillen D, Lee C, et al.
Nature
. 2023 Dec;
624(7991):317-332.
PMID: 38092916
The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional properties. Here we report...
8.
Lee B, Dalley R, Miller J, Chartrand T, Close J, Mann R, et al.
Science
. 2023 Oct;
382(6667):eadf6484.
PMID: 37824669
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling...
9.
Chartrand T, Dalley R, Close J, Goriounova N, Lee B, Mann R, et al.
Science
. 2023 Oct;
382(6667):eadf0805.
PMID: 37824667
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is...
10.
Gabitto M, Travaglini K, Rachleff V, Kaplan E, Long B, Ariza J, et al.
Res Sq
. 2023 Jun;
PMID: 37292694
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive and stereotyped accumulation of protein aggregates, but the underlying...