Luke E Formosa
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Explore the profile of Luke E Formosa including associated specialties, affiliations and a list of published articles.
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30
Citations
850
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Recent Articles
1.
Bond S, King E, Walker S, Yang C, Liu Y, Liu K, et al.
Nat Commun
. 2025 Mar;
16(1):2338.
PMID: 40057508
During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which...
2.
Wu Y, Foollee A, Chan A, Hille S, Hauke J, Challis M, et al.
Nat Commun
. 2024 Sep;
15(1):8390.
PMID: 39333498
The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little...
3.
Timpani C, Debrincat D, Kourakis S, Boyer R, Formosa L, Steele J, et al.
FASEB J
. 2024 Jun;
38(11):e23718.
PMID: 38847487
Female carriers of a Duchenne muscular dystrophy (DMD) gene mutation manifest exercise intolerance and metabolic anomalies that may be exacerbated following menopause due to the loss of estrogen, a known...
4.
Anderson A, Crameri J, Ang C, Malcolm T, Kang Y, Baker M, et al.
EMBO Rep
. 2023 Jun;
24(8):e56430.
PMID: 37272231
Human Tim8a and Tim8b are paralogous intermembrane space proteins of the small TIM chaperone family. Yeast small TIMs function in the trafficking of proteins to the outer and inner mitochondrial...
5.
Fernandez-Vizarra E, Lopez-Calcerrada S, Sierra-Magro A, Perez-Perez R, Formosa L, Hock D, et al.
Cell Metab
. 2022 Oct;
34(11):1792-1808.e6.
PMID: 36198313
The structural and functional organization of the mitochondrial respiratory chain (MRC) remains intensely debated. Here, we show the co-existence of two separate MRC organizations in human cells and postmitotic tissues,...
6.
Rius R, Bennett N, Bhattacharya K, Riley L, Yuksel Z, Formosa L, et al.
Hum Mutat
. 2022 Aug;
43(12):1970-1978.
PMID: 36030551
Primary mitochondrial diseases are a group of genetically and clinically heterogeneous disorders resulting from oxidative phosphorylation (OXPHOS) defects. COX11 encodes a copper chaperone that participates in the assembly of complex...
7.
Lu J, Azad M, Moreau J, Zhu Y, Jiang X, Tonta M, et al.
Cell Mol Life Sci
. 2022 May;
79(6):296.
PMID: 35570209
Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal...
8.
Jackson T, Crameri J, Muellner-Wong L, Frazier A, Palmer C, Formosa L, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(13):e2115566119.
PMID: 35333655
SignificanceMitochondria are double-membraned eukaryotic organelles that house the proteins required for generation of ATP, the energy currency of cells. ATP generation within mitochondria is performed by five multisubunit complexes (complexes...
9.
Formosa L, Maghool S, Sharpe A, Reljic B, Muellner-Wong L, Stroud D, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35210360
Cytochrome oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome oxidase). Although mutations in COA7 have been linked to...
10.
Van Bergen N, Massey S, Stait T, Ellery M, Reljic B, Formosa L, et al.
Neurobiol Dis
. 2021 Apr;
155:105370.
PMID: 33905871
CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental disorder caused by pathogenic variants in the Cyclin-dependent kinase-like 5 (CDKL5) gene, resulting in dysfunctional CDKL5 protein. It predominantly affects females and...