Alice J Sharpe
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Explore the profile of Alice J Sharpe including associated specialties, affiliations and a list of published articles.
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10
Citations
319
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Recent Articles
1.
Anderson A, Crameri J, Ang C, Malcolm T, Kang Y, Baker M, et al.
EMBO Rep
. 2023 Jun;
24(8):e56430.
PMID: 37272231
Human Tim8a and Tim8b are paralogous intermembrane space proteins of the small TIM chaperone family. Yeast small TIMs function in the trafficking of proteins to the outer and inner mitochondrial...
2.
Burgin H, Sharpe A, Nie S, Ziemann M, Crameri J, Stojanovski D, et al.
FEBS J
. 2022 Aug;
290(1):225-246.
PMID: 35962613
Short-chain enoyl-CoA hydratase 1 (ECHS1) is involved in the second step of mitochondrial fatty acid β-oxidation (FAO), catalysing the hydration of short-chain enoyl-CoA esters to short-chain 3-hyroxyl-CoA esters. Genetic deficiency...
3.
Jackson T, Crameri J, Muellner-Wong L, Frazier A, Palmer C, Formosa L, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(13):e2115566119.
PMID: 35333655
SignificanceMitochondria are double-membraned eukaryotic organelles that house the proteins required for generation of ATP, the energy currency of cells. ATP generation within mitochondria is performed by five multisubunit complexes (complexes...
4.
Formosa L, Maghool S, Sharpe A, Reljic B, Muellner-Wong L, Stroud D, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(9).
PMID: 35210360
Cytochrome oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome oxidase). Although mutations in COA7 have been linked to...
5.
Formosa L, Reljic B, Sharpe A, Hock D, Muellner-Wong L, Stroud D, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33879611
Mitochondrial disease is a debilitating condition with a diverse genetic etiology. Here, we report that TMEM126A, a protein that is mutated in patients with autosomal-recessive optic atrophy, participates directly in...
6.
Formosa L, Muellner-Wong L, Reljic B, Sharpe A, Jackson T, Beilharz T, et al.
Cell Rep
. 2020 Apr;
31(3):107541.
PMID: 32320651
Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The mitochondrial complex I...
7.
Dibley M, Formosa L, Lyu B, Reljic B, McGann D, Muellner-Wong L, et al.
Mol Cell Proteomics
. 2019 Nov;
19(1):65-77.
PMID: 31666358
NDUFAB1 is the mitochondrial acyl carrier protein (ACP) essential for cell viability. Through its pantetheine-4'-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family. Although several...
8.
Cheasley D, Wakefield M, Ryland G, Allan P, Alsop K, Amarasinghe K, et al.
Nat Commun
. 2019 Sep;
10(1):3935.
PMID: 31477716
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs....
9.
Kamerkar S, Kraus F, Sharpe A, Pucadyil T, Ryan M
Nat Commun
. 2018 Dec;
9(1):5239.
PMID: 30531964
Dynamin-related protein 1 (Drp1) is essential for mitochondrial and peroxisomal fission. Recent studies propose that Drp1 does not sever but rather constricts mitochondrial membranes allowing dynamin 2 (Dnm2) to execute...
10.
Sharpe A, McKenzie M
Cells
. 2018 Jun;
7(6).
PMID: 29882869
Mitochondrial fatty acid β-oxidation (FAO) is the primary pathway for fatty acid metabolism in humans, performing a key role in liver, heart and skeletal muscle energy homeostasis. FAO is particularly...