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Lukasz Szczukowski

Explore the profile of Lukasz Szczukowski including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 15
Citations 96
Followers 0
Related Specialties
Chemistry
Biochemistry
Molecular Biology
Top 10 Co-Authors
Benita Wiatrak
Piotr Swiatek
Edward Krzyzak
Aleksandra Marciniak
Aleksandra Redzicka
Adam Szelag
Marta Szandruk-Bender
Anna Merwid-Lad
Paulina Jawien
Aleksandra Kotynia
Published In
Int J Mol Sci
Inorg Chem
J Inflamm Res
Metallomics
Bioorg Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Anti-Inflammatory and Antioxidant Pyrrolo[3,4-]pyridazinone Derivatives Interact with DNA and Bind to Plasma Proteins-Spectroscopic and In Silico Studies
Kotynia A, Krzyzak E, Zadlo J, Witczak M, Szczukowski L, Mucha J, et al.
Int J Mol Sci . 2024 Feb; 25(3). PMID: 38339061
From the point of view of the search for new pharmaceuticals, pyridazinone derivatives are a very promising group of compounds. In our previous works, we have proved that newly synthesized...
2.
Synthesis, Biological, Spectroscopic and Computational Investigations of Novel -Acylhydrazone Derivatives of Pyrrolo[3,4-]pyridazinone as Dual COX/LOX Inhibitors
Mikus J, Swiatek P, Przybyla P, Krzyzak E, Marciniak A, Kotynia A, et al.
Molecules . 2023 Jul; 28(14). PMID: 37513351
Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause...
3.
Interactions of -Mannich Bases of Pyrrolo[3,4-]pyrrole with Artificial Models of Cell Membranes and Plasma Proteins, Evaluation of Anti-Inflammatory and Antioxidant Activity
Szczukowski L, Maniewska J, Wiatrak B, Jawien P, Krzyzak E, Kotynia A, et al.
Membranes (Basel) . 2023 Mar; 13(3). PMID: 36984737
Despite the widespread and easy access to NSAIDs, effective and safe treatment of various inflammatory disorders is still a serious challenge because of the severe adverse effects distinctive to these...
4.
Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-]pyridazinone Attenuates TNBS-Induced Experimental Colitis
Szandruk-Bender M, Wiatrak B, Dzimira S, Merwid-Lad A, Szczukowski L, Swiatek P, et al.
Int J Mol Sci . 2022 Sep; 23(17). PMID: 36077306
The pharmacotherapy of inflammatory bowel disease (IBD) is still not fully effective and safe. Attempts to search for new IBD drugs remain an incessant research aim. One of the novel...
5.
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test
Szandruk-Bender M, Merwid-Lad A, Wiatrak B, Danielewski M, Dzimira S, Szkudlarek D, et al.
J Inflamm Res . 2021 Nov; 14:5739-5756. PMID: 34754217
Background And Purpose: Due to the risk of gastrointestinal damage and various tissue toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs) use, investigating new anti-inflammatory agents with efficacy comparable to that...
6.
New -Substituted-1,2,4-triazole Derivatives of Pyrrolo[3,4-]pyridazinone with Significant Anti-Inflammatory Activity-Design, Synthesis and Complementary In Vitro, Computational and Spectroscopic Studies
Szczukowski L, Krzyzak E, Wiatrak B, Jawien P, Marciniak A, Kotynia A, et al.
Int J Mol Sci . 2021 Oct; 22(20). PMID: 34681894
Regarding that the chronic use of commonly available non-steroidal and anti-inflammatory drugs (NSAIDs) is often restricted by their adverse effects, there is still a current need to search for and...
7.
In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-]pyridazinone as Promising Cyclooxygenase Inhibitors
Peregrym K, Szczukowski L, Wiatrak B, Potyrak K, Czyznikowska Z, Swiatek P
Int J Mol Sci . 2021 Sep; 22(17). PMID: 34502040
Since long-term use of classic NSAIDs can cause severe side effects related mainly to the gastroduodenal tract, discovery of novel cyclooxygenase inhibitors with a safe gastric profile still remains a...
8.
Effect of pyrrolo[3,4-d]pyridazinone derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells
Potyrak K, Wiatrak B, Krzyzak E, Szczukowski L, Swiatek P, Szelag A
Biomed Pharmacother . 2021 Jul; 141:111878. PMID: 34243096
Alzheimer's disease is one of the most serious disorders of the 21st century. There is still no effective therapy for this condition. The study investigated the potential regenerative effect of...
9.
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced Gastrotoxicity
Szandruk-Bender M, Wiatrak B, Szczukowski L, Swiatek P, Rutkowska M, Dzimira S, et al.
Int J Mol Sci . 2020 Dec; 21(24). PMID: 33353118
Despite the availability of the current drug arsenal for pain management, there is still a clinical need to identify new, more effective, and safer analgesics. Based on our earlier study,...
10.
Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors
Szczukowski L, Krzyzak E, Zborowska A, Zajac P, Potyrak K, Peregrym K, et al.
Int J Mol Sci . 2020 Dec; 21(24). PMID: 33348757
The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treatment of different chronic inflammatory disorders is strongly restricted by their serious gastrointestinal adverse effects. Therefore, there is still an urgent...