Aleksandra Kotynia
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Explore the profile of Aleksandra Kotynia including associated specialties, affiliations and a list of published articles.
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19
Citations
36
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Recent Articles
1.
Marciniak A, Krzyzak E, Szkatula D, Mazurkiewicz K, Kotynia A
Molecules
. 2024 Nov;
29(22).
PMID: 39598811
The treatment of cancer represents one of the most significant challenges currently facing modern medicine. The search for new drugs that are effective in the treatment of patients is an...
2.
Krzyzak E, Marciniak A, Szkatula D, Jankowska K, Dobies N, Kotynia A
Molecules
. 2024 Aug;
29(15).
PMID: 39124935
The derivatives of isoindoline-1,3-dione are interesting due to their biological activities, such as anti-inflammatory and antibacterial effects. Several series have been designed and evaluated for Alzheimer's therapy candidates. They showed...
3.
Marciniak A, Kotynia A, Krzyzak E, Czyznikowska Z, Zielinska S, Kozlowska W, et al.
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791436
A comprehensive study of the interactions of human serum albumin (HSA) and α-1-acid glycoprotein (AAG) with two isoquinoline alkaloids, i.e., allocryptopine (ACP) and protopine (PP), was performed. The UV-Vis spectroscopy,...
4.
Kotynia A, Krzyzak E, Zadlo J, Witczak M, Szczukowski L, Mucha J, et al.
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38339061
From the point of view of the search for new pharmaceuticals, pyridazinone derivatives are a very promising group of compounds. In our previous works, we have proved that newly synthesized...
5.
Bortolus M, Kotynia A, Saielli G, Ruzza P, Di Valentin M, Carraro M, et al.
J Pept Sci
. 2024 Feb;
30(6):e3568.
PMID: 38317295
Cyclopeptides hold significant relevance in various fields of science and medicine, due to their unique structural properties and diverse biological activities. Cyclic peptides, characterized by intrinsically higher conformational order, exhibit...
6.
Szczukowski L, Maniewska J, Wiatrak B, Jawien P, Krzyzak E, Kotynia A, et al.
Membranes (Basel)
. 2023 Mar;
13(3).
PMID: 36984737
Despite the widespread and easy access to NSAIDs, effective and safe treatment of various inflammatory disorders is still a serious challenge because of the severe adverse effects distinctive to these...
7.
Krzyzak E, Kotynia A, Szkatula D, Marciniak A
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983915
One of the groups of organic compounds with potential use in medicine and pharmacy is phthalimide derivatives. They are characterized by a wide range of properties such as antibacterial, antifungal,...
8.
Kotynia A, Marciniak A, Kamysz W, Neubauer D, Krzyzak E
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769160
In this project, we combine two areas of research, experimental characterization and molecular docking studies of the interaction of positively charged oligopeptides with crucial blood plasma proteins. The investigated peptides...
9.
Marciniak A, Kotynia A, Szkatula D, Krzyzak E
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806006
Many publications in databases deal with the interactions of new drugs with albumin. However, it is not only albumin that is responsible for binding pharmaceutical molecules to proteins in the...
10.
Cationic Peptides and Their Cu(II) and Ni(II) Complexes: Coordination and Biological Characteristics
Kotynia A, Wiatrak B, Kamysz W, Neubauer D, Jawien P, Marciniak A
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34769458
Antimicrobial peptides are a promising group of compounds used for the treatment of infections. In some cases, metal ions are essential to activate these molecules. Examples of metalloantibiotics are, for...