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Lukasz Czekala

Explore the profile of Lukasz Czekala including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 101
Followers 0
Related Specialties
Biology
Toxicology
Pharmacology
Top 10 Co-Authors
Matthew Stevenson
Liam Simms
Edgar Trelles Sticken
Tanvir Walele
Roman Wieczorek
Kathryn Rudd
Fan Yu
Fiona Chapman
Grant OConnell
Jessica Budde
Published In
Curr Res Toxicol
Regul Toxicol Pharmacol
Toxicol In Vitro
Front Toxicol
Plant Physiol Biochem
Affiliations
Soon will be listed here.
Recent Articles
1.
Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke
Chapman F, Pour S, Wieczorek R, Sticken E, Budde J, Rower K, et al.
Front Toxicol . 2023 Mar; 5:1076752. PMID: 36875887
Tobacco harm reduction (THR) involves providing adult smokers with potentially reduced harm modes of nicotine delivery as alternatives to smoking combustible cigarettes. Heated tobacco products (HTPs) form a category with...
2.
Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette
Chapman F, Sticken E, Wieczorek R, Pour S, Dethloff O, Budde J, et al.
Toxicol In Vitro . 2022 Nov; 86:105510. PMID: 36372310
This study aimed to compare the aerosol chemistry and in vitro toxicological profiles of two prototype Heated Tobacco Product (p-HTP) variants to the 1R6F Reference Cigarette. In the neutral red...
3.
Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products
Simms L, Yu F, Palmer J, Rudd K, Sticken E, Wieczorek R, et al.
Front Toxicol . 2022 Mar; 4:747508. PMID: 35295225
Combustible cigarette smoking is an established risk factor for cardiovascular disease. By contrast, the cardiotoxicity potential of non-combustible next generation nicotine products (NGPs), which includes heated tobacco products (HTPs) and...
4.
Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes
Simms L, Mason E, Berg E, Yu F, Rudd K, Czekala L, et al.
Curr Res Toxicol . 2021 Sep; 2:309-321. PMID: 34485931
A growing number of public health bodies, regulators and governments around the world consider electronic vapor products a lower risk alternative to conventional cigarettes. Of critical importance are rapid new...
5.
Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke
Czekala L, Wieczorek R, Simms L, Yu F, Budde J, Sticken E, et al.
Curr Res Toxicol . 2021 Aug; 2:99-115. PMID: 34345855
Smoking is a cause of serious diseases in smokers including chronic respiratory diseases. This study aimed to evaluate the tobacco harm reduction (THR) potential of an electronic vapor product (EVP,...
6.
The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes
Simms L, Rudd K, Palmer J, Czekala L, Yu F, Chapman F, et al.
Curr Res Toxicol . 2021 Aug; 1:161-173. PMID: 34345845
devTOX Predict (devTOX ) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity Developmental toxicity potential is...
7.
The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols
Czekala L, Chapman F, Simms L, Rudd K, Sticken E, Wieczorek R, et al.
Mutagenesis . 2021 Mar; 36(2):129-142. PMID: 33769537
In vitro (geno)toxicity assessment of electronic vapour products (EVPs), relative to conventional cigarette, currently uses assays, including the micronucleus and Ames tests. Whilst informative on induction of a finite endpoint...
8.
High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate
Czekala L, Simms L, Stevenson M, Trelles-Sticken E, Walker P, Walele T
Toxicol In Vitro . 2019 Mar; 58:86-96. PMID: 30880017
There is scientific agreement that the detrimental effects of cigarettes are produced by the formation of Harmful and Potentially Harmful Constituents from tobacco combustion and not by nicotine. For this...
9.
Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model
Czekala L, Simms L, Stevenson M, Tschierske N, Maione A, Walele T
Regul Toxicol Pharmacol . 2019 Feb; 103:314-324. PMID: 30721718
With the growing prevalence of e-cigarettes as an alternative to conventional cigarettes amongst smokers worldwide, there is a need for new methods to evaluate their relative toxicological profile as part...
10.
The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e-liquids
Stevenson M, Czekala L, Simms L, Tschierske N, Larne O, Walele T
Regul Toxicol Pharmacol . 2019 Jan; 103:158-165. PMID: 30629970
Electronic cigarettes (e-cigarettes) are an increasingly popular alternative to combustible tobacco cigarettes among smokers worldwide. A growing body of research indicates that flavours play a critical role in attracting and...