Lukasz A Joachimiak
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Explore the profile of Lukasz A Joachimiak including associated specialties, affiliations and a list of published articles.
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46
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1325
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Recent Articles
11.
Hitt B, Gupta A, Singh R, Yang T, Beaver J, Shang P, et al.
J Biol Chem
. 2023 Sep;
299(11):105252.
PMID: 37714465
Neurodegenerative tauopathies are caused by the transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and...
12.
Perez V, Sanders D, Mendoza-Oliva A, Stopschinski B, Mullapudi V, White C, et al.
Elife
. 2023 Jun;
12.
PMID: 37387473
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate....
13.
Li L, Nguyen B, Mullapudi V, Li Y, Saelices L, Joachimiak L
Structure
. 2023 Jun;
31(9):1025-1037.e4.
PMID: 37348495
Assembly of tau into beta-sheet-rich amyloids dictates the pathology of a diversity of diseases. Lysine acetylation has been proposed to drive tau amyloid assembly, but no direct mechanism has emerged....
14.
Rios M, Bagnucka M, Ryder B, Ferreira Gomes B, Familiari N, Yaguchi K, et al.
bioRxiv
. 2023 Jun;
PMID: 37293020
During mitotic spindle assembly, microtubules generate tensile stresses on pericentriolar material (PCM), the outermost layer of centrosomes. The molecular interactions that enable PCM to assemble rapidly and resist external forces...
15.
Rios M, Ryder B, Familiari N, Joachimiak L, Woodruff J
bioRxiv
. 2023 Jun;
PMID: 37292920
Centrosomes organize microtubules for mitotic spindle assembly and positioning. Forces mediated by these microtubules create tensile stresses on pericentriolar material (PCM), the outermost layer of centrosomes. How PCM resists these...
16.
Wydorski P, Osipiuk J, Lanham B, Tesar C, Endres M, Engle E, et al.
Nat Commun
. 2023 May;
14(1):2366.
PMID: 37185902
The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with poly-ubiquitin and protective ISG15, composed of two...
17.
Perez V, Sanders D, Mendoza-Oliva A, E Stopschinski B, Mullapudi V, White 3rd C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993367
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate....
18.
Chen D, Bali S, Singh R, Wosztyl A, Mullapudi V, Vaquer-Alicea J, et al.
Nat Commun
. 2023 Mar;
14(1):1625.
PMID: 36959205
Amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau), missense mutations in tau enhance its aggregation propensity. Here we describe...
19.
Mullapudi V, Vaquer-Alicea J, Bommareddy V, Vega A, Ryder B, White 3rd C, et al.
Nat Commun
. 2023 Feb;
14(1):895.
PMID: 36797278
Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can adopt a diversity of...
20.
Li L, Nguyen B, Mullapudi V, Saelices L, Joachimiak L
bioRxiv
. 2023 Jan;
PMID: 36711822
Assembly of the microtubule-associated protein into tauopathy fibril conformations dictates the pathology of a diversity of diseases. Recent cryogenic Electron Microscopy (cryo-EM) structures have uncovered distinct fibril conformations in different...