Luis Alarcon-Martinez
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Explore the profile of Luis Alarcon-Martinez including associated specialties, affiliations and a list of published articles.
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30
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1264
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Recent Articles
1.
Shiga Y, Olguin A, El Hajji S, Belforte N, Quintero H, Dotigny F, et al.
Cell Rep Med
. 2024 Nov;
5(12):101839.
PMID: 39615485
Disruption of calcium (Ca) homeostasis in neurons is a hallmark of neurodegenerative diseases. Here, we investigate the mechanisms leading to Ca dysregulation and ask whether altered Ca dynamics impinge on...
2.
Kumar S, Hsiao Y, Wong V, Aubin D, Wang J, Lisowski L, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(45):e2408345121.
PMID: 39475642
CRISPR-Cas13 nucleases are programmable RNA-targeting effectors that can silence gene expression in a transient manner. Recent iterations of Cas13 nucleases are compact for adeno-associated virus (AAV) delivery to achieve strong...
3.
McDonald H, Gardner-Russell J, Alarcon-Martinez L
Results Probl Cell Differ
. 2024 Sep;
73:229-247.
PMID: 39242382
The retina transforms light into electrical signals, which are sent to the brain via the optic nerve to form our visual perception. This complex signal processing is performed by the...
4.
Alarcon-Martinez L, Shiga Y, Villafranca-Baughman D, Cueva Vargas J, Vidal Paredes I, Quintero H, et al.
Prog Retin Eye Res
. 2023 Oct;
97:101217.
PMID: 37778617
Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The timely regulation of...
5.
Quintero H, Shiga Y, Belforte N, Alarcon-Martinez L, El Hajji S, Villafranca-Baughman D, et al.
Cell Rep
. 2022 Sep;
40(11):111324.
PMID: 36103832
Deficits in mitochondrial transport are a common feature of neurodegenerative diseases. We investigated whether loss of components of the mitochondrial transport machinery impinge directly on metabolic stress, neuronal death, and...
6.
Alarcon-Martinez L, Shiga Y, Villafranca-Baughman D, Belforte N, Quintero H, Dotigny F, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(7).
PMID: 35135877
Reduced blood flow and impaired neurovascular coupling are recognized features of glaucoma, the leading cause of irreversible blindness worldwide, but the mechanisms underlying these defects are unknown. Retinal pericytes regulate...
7.
Belforte N, Agostinone J, Alarcon-Martinez L, Villafranca-Baughman D, Dotigny F, Cueva Vargas J, et al.
Mol Neurodegener
. 2021 Jun;
16(1):43.
PMID: 34187514
Background: The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative diseases, yet...
8.
Alarcon-Martinez L, Yemisci M, Dalkara T
Histol Histopathol
. 2021 Feb;
36(6):633-643.
PMID: 33595091
The proper delivery of blood is essential for healthy neuronal function. The anatomical substrate for this precise mechanism is the neurovascular unit, which is formed by neurons, glial cells, endothelia,...
9.
Alarcon-Martinez L, Villafranca-Baughman D, Quintero H, Kacerovsky J, Dotigny F, Murai K, et al.
Nature
. 2020 Aug;
585(7823):91-95.
PMID: 32788726
Signalling between cells of the neurovascular unit, or neurovascular coupling, is essential to match local blood flow with neuronal activity. Pericytes interact with endothelial cells and extend processes that wrap...
10.
Alarcon-Martinez L, Yilmaz-Ozcan S, Yemisci M, Schallek J, Kilic K, Villafranca-Baughman D, et al.
Acta Neuropathol Commun
. 2019 Aug;
7(1):134.
PMID: 31429795
Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological roles in various neurodegenerative processes. Microvascular pericytes contract during cerebral and coronary ischemia and do not relax after re-opening of...