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» Authors » Luigi G Marzilli

Luigi G Marzilli

Explore the profile of Luigi G Marzilli including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 79
Citations 408
Followers 0
Related Specialties
Chemistry
Nuclear Medicine
Biology
Top 10 Co-Authors
Patricia A Marzilli
Giovanni Natile
Malgorzata Lipowska
Andrew T Taylor
Frank R Fronczek
Xiaolong Xu
Jamil S Saad
Francesco P Intini
Renzo Cini
Lory Hansen
Published In
Inorg Chem
J Nucl Med
J Am Chem Soc
Acta Crystallogr B
Nucl Med Biol
Affiliations
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Recent Articles
1.
-Tc/Re-tricarbonyl complexes with tridentate aminocarboxyphosphonate ligands: suitability of the phosphonate group in chelate ligand design of new imaging agents
Lipowska M, Klenc J, Taylor A, Marzilli L
Inorganica Chim Acta . 2019 Feb; 486:529-537. PMID: 30804606
Ligands that coordinate via dianionic phosphonate groups have not been widely utilized in radiopharmaceuticals. -(phosphonomethyl)iminodiacetic acid (, PMIDA) and (phosphonomethyl)glycine (, PMG) were investigated as new chelators for the Tc/Re-tricarbonyl...
2.
Linear Bidentate Ligands (L) with Two Terminal Pyridyl N-Donor Groups Forming Pt(II)LCl Complexes with Rare Eight-Membered Chelate Rings
Ranasinghe K, Marzilli P, Pakhomova S, Marzilli L
Inorg Chem . 2018 Oct; 57(20):12756-12768. PMID: 30281298
NMR and X-ray diffraction studies were conducted on Pt(II)LCl complexes prepared with the new N-donor ligands N(SOR)Me dpa (R = Me, Tol; n = 2, 4). These ligands differ from...
3.
Synthesis and Characterization of Pt(II) Complexes with Pyridyl Ligands: Elongated Octahedral Ion Pairs and Other Factors Influencing H NMR Spectra
Lewis N, Pakhomova S, Marzilli P, Marzilli L
Inorg Chem . 2017 Aug; 56(16):9781-9793. PMID: 28771331
Our goal is to develop convenient methods for obtaining trans-[Pt(4-Xpy)Cl] complexes applicable to 4-substituted pyridines (4-Xpy) with limited volatility and water solubility, properties typical of 4-Xpy, with X being a...
4.
A Very Rare Example of a Structurally Characterized 3'-GMP Metal Complex. NMR and Synthetic Assessment of Adducts Formed by Guanine Derivatives with [Pt(L)Cl]Cl Complexes with an N,N',N″ Tridentate Ligand (L) Terminated by Imidazole Rings
Ranasinghe K, Pakhomova S, Marzilli P, Marzilli L
Inorg Chem . 2017 Jul; 56(14):8462-8477. PMID: 28682064
[Pt(N(R)-1,1'-Medma)Cl]Cl complexes with tridentate ligands (bis(1-methyl-2-methylimidazolyl)amine, R = H; N-(methyl)bis(1-methyl-2-methylimidazolyl)amine, R = Me) were prepared in order to investigate Pt(N(R)-1,1'-Medma)G adducts (G = monodentate N9-substituted guanine or hypoxanthine derivative). Solution...
5.
Monoanionic Tc-tricarbonyl-aminopolycarboxylate complexes with uncharged pendant groups: Radiosynthesis and evaluation as potential renal tubular tracers
Lipowska M, Klenc J, Jarkas N, Marzilli L, Taylor A
Nucl Med Biol . 2017 Jan; 47:48-55. PMID: 28110124
Introduction: Tc(CO)-nitrilotriacetic acid, Tc(CO)(NTA), is a new renal tubular agent with pharmacokinetic properties comparable to those of I-OIH but the clearance of Tc(CO)(NTA) and I-OIH is still less than the...
6.
Guanine nucleobase adducts formed by a monofunctional complex: [Pt(N-(6-methyl-2-picolyl)-N-(2-picolyl)amine)Cl]Cl
Andrepont C, Marzilli P, Pakhomova S, Marzilli L
J Inorg Biochem . 2015 Aug; 153:219-230. PMID: 26239547
Monofunctional Pt(II) complexes bind to G residues in DNA and, if the carrier ligands are bulky, cause DNA structural distortions that lead to anticancer activity. We assessed the steric effects...
7.
Structure and Properties of fac-[Re(I)(CO)3(NTA)](2-) (NTA(3-) = Trianion of Nitrilotriacetic Acid) and fac-[Re(I)(CO)3(L)](n-) Analogues Useful for Assessing the Excellent Renal Clearance of the fac-[(99m)Tc(I)(CO)3(NTA)](2-) Diagnostic Renal Agent
Klenc J, Lipowska M, Abhayawardhana P, Taylor A, Marzilli L
Inorg Chem . 2015 Jun; 54(13):6281-90. PMID: 26068141
We previously identified two new agents based on the [(99m)Tc(V)O](3+) core with renal clearances in human volunteers 30% higher than that of the widely used clinical tracer (99m)Tc-MAG3 (MAG3(5-) =...
8.
Unusual Example of Chelate Ring Opening upon Coordination of the 9-Ethylguanine Nucleobase to [Pt(di-(6-methyl-2-picolyl)amine)Cl]Cl
Andrepont C, Pakhomova S, Marzilli P, Marzilli L
Inorg Chem . 2015 Apr; 54(10):4895-908. PMID: 25910178
Anticancer-active monofunctional Pt(II) complexes have bulky carrier ligands and bind to G residues in DNA, causing structural distortions. To gain fundamental chemical information on such monofunctional adducts, we assessed the...
9.
Models for B12-conjugated radiopharmaceuticals. Cobaloxime binding to new fac-[Re(CO)3(Me2bipyridine)(amidine)]BF4 complexes having an exposed pyridyl nitrogen
Lewis N, Marzilli P, Fronczek F, Marzilli L
Inorg Chem . 2014 Oct; 53(20):11096-107. PMID: 25285912
New mononuclear amidine complexes, fac-[Re(CO)3(Me2bipy)(HNC(CH3)(pyppz))]BF4 [(4,4'-Me2bipy (1), 5,5'-Me2bipy (2), and 6,6'-Me2bipy (3)] (bipy = 2,2'-bipyridine), were synthesized by treating the parent fac-[Re(I)(CO)3(Me2bipy)(CH3CN)]BF4 complex with the C2-symmetrical amine 1-(4-pyridyl)piperazine (pyppzH). The...
10.
DNA fragment conformations in adducts with Kiteplatin
Margiotta N, Petruzzella E, Platts J, Mutter S, Deeth R, Ranaldo R, et al.
Dalton Trans . 2014 Aug; 44(8):3544-56. PMID: 25144401
The anticancer activity of cisplatin is triggered by its formation of intrastrand adducts involving adjacent G residues of DNA. To obtain information on the different conformers that can be formed,...