Ludwig Lehle
Overview
Explore the profile of Ludwig Lehle including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
1079
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Recent Articles
1.
Buettner F, Ashikov A, Tiemann B, Lehle L, Bakker H
Mol Cell
. 2013 Apr;
50(2):295-302.
PMID: 23562325
Among the different types of protein glycosylation, C-mannosylation of tryptophan residues stands out because of the unique linkage formed between sugar and protein. Instead of the typical O- or N-glycosidic...
2.
Berends E, Lehle L, Henquet M, Hesselink T, Wosten H, Lugones L, et al.
Glycobiology
. 2012 Sep;
23(2):147-54.
PMID: 22997240
Alg3 of Saccharomyces cerevisiae catalyzes the mannosyl transfer from Man-P-Dol to Man(5)GlcNAc(2)-PP-Dol resulting in the formation of Man(6)GlcNAc(2)-PP-Dol, which is then further processed to the final precursor oligosaccharide Glc(3)Man(9)GlcNAc(2) for...
3.
Morava E, Vodopiutz J, Lefeber D, Janecke A, Schmidt W, Lechner S, et al.
Pediatrics
. 2012 Sep;
130(4):e1034-9.
PMID: 22966035
Deficiency of β-1,4 mannosyltransferase (MT-1) congenital disorder of glycosylation (CDG), due to ALG1 gene mutations. Features in 9 patients reported previously consisted of prenatal growth retardation, pregnancy-induced maternal hypertension and...
4.
Tanner W, Lehle L
Biochem Biophys Res Commun
. 2012 Aug;
425(3):578-82.
PMID: 22925677
No abstract available.
5.
Timal S, Hoischen A, Lehle L, Adamowicz M, Huijben K, Sykut-Cegielska J, et al.
Hum Mol Genet
. 2012 Apr;
21(19):4151-61.
PMID: 22492991
Congenital disorders of glycosylation type I (CDG-I) form a growing group of recessive neurometabolic diseases. Identification of disease genes is compromised by the enormous heterogeneity in clinical symptoms and the...
6.
Pasikowska M, Palamarczyk G, Lehle L
Glycobiology
. 2012 Apr;
22(7):939-47.
PMID: 22492205
Rot1 is an essential yeast protein originally shown to be implicated in such diverse processes such as β-1,6-glucan synthesis, actin cytoskeleton dynamics or lysis of autophagic bodies. More recently also...
7.
Lefeber D, de Brouwer A, Morava E, Riemersma M, Schuurs-Hoeijmakers J, Absmanner B, et al.
PLoS Genet
. 2012 Jan;
7(12):e1002427.
PMID: 22242004
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in...
8.
Morava E, Wevers R, Cantagrel V, Hoefsloot L, Al-Gazali L, Schoots J, et al.
Brain
. 2010 Sep;
133(11):3210-20.
PMID: 20852264
Cerebellar hypoplasia and slowly progressive ophthalmological symptoms are common features in patients with congenital disorders of glycosylation type I. In a group of patients with congenital disorders of glycosylation type...
9.
Cantagrel V, Lefeber D, Ng B, Guan Z, Silhavy J, Bielas S, et al.
Cell
. 2010 Jul;
142(2):203-17.
PMID: 20637498
N-linked glycosylation is the most frequent modification of secreted and membrane-bound proteins in eukaryotic cells, disruption of which is the basis of the congenital disorders of glycosylation (CDGs). We describe...
10.
Rind N, Schmeiser V, Thiel C, Absmanner B, Lubbehusen J, Hocks J, et al.
Hum Mol Genet
. 2010 Jan;
19(8):1413-24.
PMID: 20080937
A new type of congenital disorders of glycosylation, designated CDG-Ip, is caused by the deficiency of GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, encoded by the human ortholog of ALG11 from yeast. The patient presented with...