Lucy Mathot
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Explore the profile of Lucy Mathot including associated specialties, affiliations and a list of published articles.
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17
Citations
177
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Recent Articles
1.
Nunes L, Li F, Wu M, Luo T, Hammarstrom K, Torell E, et al.
Nature
. 2024 Aug;
633(8028):137-146.
PMID: 39112715
Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations,...
2.
Hammarstrom K, Nunes L, Mathot L, Mezheyeuski A, Lundin E, Korsavidou Hult N, et al.
Int J Cancer
. 2024 Feb;
155(1):40-53.
PMID: 38376070
Rectal cancer poses challenges in preoperative treatment response, with up to 30% achieving a complete response (CR). Personalized treatment relies on accurate identification of responders at diagnosis. This study aimed...
3.
Sandberg E, Nunes L, Edqvist P, Mathot L, Chen L, Edgren T, et al.
Cancers (Basel)
. 2024 Feb;
16(3).
PMID: 38339300
Mutation analysis of circulating tumor DNA (ctDNA) has applications in monitoring of colorectal cancer (CRC) patients for recurrence. Considering the low tumor fraction of ctDNA in cell-free DNA (cfDNA) isolated...
4.
Kundu S, Nunes L, Adler J, Mathot L, Stoimenov I, Sjoblom T
Cell Commun Signal
. 2023 Dec;
21(1):354.
PMID: 38102712
Background: Ephrin (EPH) receptors have been implicated in tumorigenesis and metastasis, but the functional understanding of mutations observed in human cancers is limited. We previously demonstrated reduced cell compartmentalisation for...
5.
Eriksson A, Engvall M, Mathot L, Osterroos A, Rippin M, Cavelier L, et al.
Clin Cancer Res
. 2023 Apr;
29(15):2826-2834.
PMID: 37022349
Purpose: In acute myeloid leukemia (AML), somatic mutations (commonly missense, nonsense, and frameshift indels) in RUNX1 are associated with a dismal clinical outcome. Inherited RUNX1 mutations cause familial platelet disorder....
6.
Engvall M, Karlsson Y, Kuchinskaya E, Jornegren A, Mathot L, Pandzic T, et al.
Leuk Lymphoma
. 2022 May;
63(10):2311-2320.
PMID: 35533071
Germline pathogenic variants in are associated with familial platelet disorder with predisposition to myeloid malignancies (FPD/MM) with intragenic deletions in accounting for almost 7% of all reported variants. We present...
7.
Zhao L, Xing P, Polavarapu V, Zhao M, Valero-Martinez B, Dang Y, et al.
Nucleic Acids Res
. 2021 Sep;
49(21):e125.
PMID: 34534335
The majority of biopsies in both basic research and translational cancer studies are preserved in the format of archived formalin-fixed paraffin-embedded (FFPE) samples. Profiling histone modifications in archived FFPE tissues...
8.
Zhang H, Polavarapu V, Xing P, Zhao M, Mathot L, Zhao L, et al.
Genome Res
. 2021 Jul;
32(1):150-161.
PMID: 34261731
Archived formalin-fixed paraffin-embedded (FFPE) samples are the global standard format for preservation of the majority of biopsies in both basic research and translational cancer studies, and profiling chromatin accessibility in...
9.
Nunes L, Aasebo K, Mathot L, Ljungstrom V, Edqvist P, Sundstrom M, et al.
Acta Oncol
. 2020 Jan;
59(4):417-426.
PMID: 31924107
We have reported that V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from clinical trials...
10.
Mathot L, Kundu S, Ljungstrom V, Svedlund J, Moens L, Adlerteg T, et al.
Cancer Res
. 2017 Jan;
77(7):1730-1740.
PMID: 28108514
The contribution of somatic mutations to metastasis of colorectal cancers is currently unknown. To find mutations involved in the colorectal cancer metastatic process, we performed deep mutational analysis of 676...