Lucy Her
Overview
Explore the profile of Lucy Her including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
49
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Recent Articles
1.
Robarge J, Budge K, Her L, Patterson A, Brown-Augsburger P
Antibodies (Basel)
. 2025 Jan;
14(1.
PMID: 39846610
Background: The prediction of human clearance (CL) and subcutaneous (SC) bioavailability is a critical aspect of monoclonal antibody (mAb) selection for clinical development. While monkeys are a well-accepted model for...
2.
Her L, Shi J, Wang X, He B, Smith L, Jiang H, et al.
Proteomics
. 2022 Nov;
23(1):e2200176.
PMID: 36413357
It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non-genetic regulators. The mRNA allele-specific expression (ASE) assay has been increasingly used...
3.
Xiao J, Shi J, Li R, Her L, Wang X, Li J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2021 Aug;
1179:122865.
PMID: 34365292
Most medications prescribed to neonatal patients are off-label uses. The pharmacokinetics and pharmacodynamics of drugs differ significantly between neonates and adults. Therefore, personalized pharmacotherapy guided by therapeutic drug monitoring (TDM)...
4.
Wang X, Her L, Xiao J, Shi J, Wu A, Bleske B, et al.
Clin Transl Sci
. 2021 Mar;
14(4):1380-1389.
PMID: 33660934
Trandolapril, an angiotensin-converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect. A previous in vitro study demonstrated that...
5.
Shi J, Xiao J, Li J, Wang X, Her L, Sorensen M, et al.
Proteomics
. 2020 Oct;
20(24):e2000175.
PMID: 33085175
Multidimensional fractionation-based enrichment methods improve the sensitivity of proteomic analysis for low-abundance proteins. However, a major limitation of conventional multidimensional proteomics is the extensive labor and instrument time required for...
6.
Her L, Zhu H
Drug Metab Dispos
. 2019 Dec;
48(3):230-244.
PMID: 31871135
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%-95% of total hydrolytic activity in...