Lucy H Clerk
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Explore the profile of Lucy H Clerk including associated specialties, affiliations and a list of published articles.
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11
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849
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Recent Articles
1.
Keske M, Clerk L, Price W, Jahn L, Barrett E
Diabetes Care
. 2009 Jun;
32(9):1672-7.
PMID: 19487636
Objective: Ingestion of a mixed meal recruits flow to muscle capillaries and increases total forearm blood flow in healthy young lean people. We examined whether these vascular responses are blunted...
2.
Clerk L, Vincent M, Barrett E, Lankford M, Lindner J
Am J Physiol Endocrinol Metab
. 2007 Oct;
293(6):E1804-9.
PMID: 17911341
Acute physiological hyperinsulinemia increases skeletal muscle capillary blood volume (CBV), presumably to augment glucose and insulin delivery. We hypothesized that insulin-mediated changes in CBV are impaired in type 2 diabetes...
3.
Inyard A, Clerk L, Vincent M, Barrett E
Diabetes
. 2007 Jun;
56(9):2194-200.
PMID: 17563063
We examined whether contraction-induced muscle microvascular recruitment would expand the surface area for insulin and nutrient exchange and thereby contribute to insulin-mediated glucose disposal. We measured in vivo rat hindlimb...
4.
Vincent M, Clerk L, Lindner J, Price W, Jahn L, Leong-Poi H, et al.
Am J Physiol Endocrinol Metab
. 2006 May;
290(6):E1191-7.
PMID: 16682488
Intense exercise and insulin each increases total limb blood flow and recruits muscle capillaries, presumably to facilitate nutrient exchange. Whether mixed meals or light exercise likewise recruits capillaries is unknown....
5.
Clerk L, Vincent M, Jahn L, Liu Z, Lindner J, Barrett E
Diabetes
. 2006 Apr;
55(5):1436-42.
PMID: 16644702
We have previously shown that skeletal muscle capillaries are rapidly recruited by physiological doses of insulin in both humans and animals. This facilitates glucose and insulin delivery to muscle, thus...
6.
Vincent M, Clerk L, Rattigan S, Clark M, Barrett E
Clin Exp Pharmacol Physiol
. 2005 Apr;
32(4):302-7.
PMID: 15810996
1. In the 80+ years since insulin's discovery, an enormous amount of literature has accumulated relating to its actions on body fat, glucose and protein metabolism. In particular, skeletal muscle...
7.
Vincent M, Clerk L, Lindner J, Klibanov A, Clark M, Rattigan S, et al.
Diabetes
. 2004 May;
53(6):1418-23.
PMID: 15161743
Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow and to recruit muscle capillaries...
8.
Zhang L, Vincent M, Richards S, Clerk L, Rattigan S, Clark M, et al.
Diabetes
. 2004 Jan;
53(2):447-53.
PMID: 14747297
We have reported that insulin exerts two vascular actions in muscle; it both increases blood flow and recruits capillaries. In parallel hyperinsulinemic-euglycemic clamp studies, we compared the insulin dose response...
9.
Clerk L, Vincent M, Lindner J, Clark M, Rattigan S, Barrett E
Diabetes Metab Res Rev
. 2004 Jan;
20(1):3-12.
PMID: 14737741
Whether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of...
10.
Clark M, Wallis M, Barrett E, Vincent M, Richards S, Clerk L, et al.
Am J Physiol Endocrinol Metab
. 2003 Jan;
284(2):E241-58.
PMID: 12531739
The vascular system controls the delivery of nutrients and hormones to muscle, and a number of hormones may act to regulate muscle metabolism and contractile performance by modulating blood flow...