Lucy G Andrews
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Explore the profile of Lucy G Andrews including associated specialties, affiliations and a list of published articles.
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28
Citations
797
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Recent Articles
1.
Phipps S, Love W, White T, Andrews L, Tollefsbol T
Anticancer Res
. 2010 Jan;
29(12):4959-64.
PMID: 20044602
Background: Multiple mechanisms regulate cancer-associated telomerase activity at the level of human telomerase reverse transcriptase (hTERT) transcription which may serve as novel targets for anticancer approaches. Materials And Methods: The...
2.
Li Y, Liu L, Andrews L, Tollefsbol T
Int J Cancer
. 2009 Apr;
125(2):286-96.
PMID: 19358274
Genistein, a natural isoflavone found in soybean products, has been reported to down-regulate telomerase activity and that this prevents cancer and contributes to the apoptosis of cancer cells. However, the...
3.
Phipps S, Love W, Mott T, Andrews L, Tollefsbol T
Mol Biotechnol
. 2008 Oct;
41(3):201-7.
PMID: 18953677
Although the progression of aging and the diseases associated with it are extensively studied, little is known about the initiation of the aging process. Telomerase is down-regulated early in embryonic...
4.
Love W, Deangelis J, Berletch J, Phipps S, Andrews L, Brouillette W, et al.
Transl Oncol
. 2008 Sep;
1(3):148-52.
PMID: 18795149
Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia...
5.
Retrovirus-mediated RNA interference. Targeting hTERT through stable expression of short-hairpin RNA
Cunningham A, Andrews L, Tollefsbol T
Methods Mol Biol
. 2008 Mar;
405:39-46.
PMID: 18369816
RNA interference (RNAi) has recently emerged as a reliable tool for studying the effects of knocking down or ablating the expression of specific genes. It is hoped that progress made...
6.
Lai S, Andrews L, Tollefsbol T
Methods Mol Biol
. 2008 Mar;
405:31-7.
PMID: 18369815
RNA interference (RNAi) is one of the most commonly used procedures for gene targeting in today's cutting edge technology and has great potential for use in clinical therapy. Using a...
7.
Lai S, Andrews L, Tollefsbol T
Methods Mol Biol
. 2008 Mar;
405:23-9.
PMID: 18369814
The method of RNA interference (RNAi) is an easy means of knocking down a gene without having to generate knockout mutants, which may prove to be difficult and time consuming....
8.
Andrews L, Tollefsbol T
Methods Mol Biol
. 2008 Mar;
405:1-7.
PMID: 18369812
Telomerase is central to cellular immortality and is a key component of most cancer cells although this enzyme is rarely expressed to significant levels in normal cells. Therefore, the inhibition...
9.
Love W, Berletch J, Andrews L, Tollefsbol T
Int J Oncol
. 2008 Feb;
32(3):625-31.
PMID: 18292940
Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting...
10.
Berletch J, Phipps S, Walthall S, Andrews L, Tollefsbol T
Methods Mol Biol
. 2007 Jul;
371:81-7.
PMID: 17634575
The methylation of CpG dinucleotides located in key protein binding sites within gene regulatory regions often leads to gene silencing. A mechanism of aging is proposed whereby an accumulation of...