Lucie E Bourne
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Explore the profile of Lucie E Bourne including associated specialties, affiliations and a list of published articles.
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11
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97
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Recent Articles
1.
Bourne L, Jayash S, Michels L, Hopkinson M, Guppy F, Clarkin C, et al.
Biol Sex Differ
. 2024 Jun;
15(1):51.
PMID: 38890762
Background: Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and is associated with childhood growth deficiencies and increased bone fracture risk. However,...
2.
Bourne L, Hesketh A, Sharma A, Bucca G, Bush P, Staines K
Front Endocrinol (Lausanne)
. 2023 Dec;
14:1278596.
PMID: 38144567
Introduction: Chondrocytes are continuously exposed to loads placed upon them. Physiological loads are pivotal to the maintenance of articular cartilage health, while abnormal loads contribute to pathological joint degradation. Similarly,...
3.
Bourne L, Davies B, Millan J, Arnett T, Wheeler-Jones C, Keen J, et al.
Bone
. 2023 Aug;
176:116868.
PMID: 37549801
Extracellular pyrophosphate (PP) is well known for its fundamental role as a physiochemical mineralisation inhibitor. However, information about its direct actions on bone cells remains limited. This study shows that...
4.
Orriss I, Davies B, Bourne L, Arnett T
Purinergic Signal
. 2022 Aug;
19(2):367-378.
PMID: 35976527
Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of these. One exception is the P2X4 receptor,...
5.
Bourne L, Patel J, Davies B, Neven E, Verhulst A, DHaese P, et al.
J Cell Physiol
. 2021 Oct;
237(1):1070-1086.
PMID: 34658034
Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone formation; however, emerging evidence suggests several key...
6.
Bourne L, Wheeler-Jones C, Orriss I
J Endocrinol
. 2020 Dec;
248(2):R51-R65.
PMID: 33337345
Biomineralisation, the deposition of mineral onto a matrix, can be both a physiological and pathological process. Bone formation involves the secretion of an extracellular matrix (ECM) by osteoblasts and subsequent...
7.
Patel J, Bourne L, Thakur S, Farrington K, Gorog D, Orriss I, et al.
J Cell Physiol
. 2020 Sep;
236(4):2696-2705.
PMID: 32918744
Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of...
8.
Patel J, Bourne L, Millan J, Arnett T, Macrae V, Wheeler-Jones C, et al.
Purinergic Signal
. 2019 Jul;
15(3):315-326.
PMID: 31338672
Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous work has shown that ATP/UTP can inhibit...
9.
Patel J, Bourne L, Davies B, Arnett T, Macrae V, Wheeler-Jones C, et al.
Exp Cell Res
. 2019 Apr;
380(1):100-113.
PMID: 31004580
Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has...
10.
Perpetuo I, Bourne L, Orriss I
Methods Mol Biol
. 2019 Feb;
1914:21-38.
PMID: 30729458
This chapter describes the isolation, culture, and staining of osteoblasts. The key advantages of this assay are that it allows direct measurement of bone matrix deposition and mineralization, as well...