Lucie Crouzier
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Explore the profile of Lucie Crouzier including associated specialties, affiliations and a list of published articles.
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17
Citations
181
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Recent Articles
1.
Garcia-Pupo L, Crouzier L, Bencomo-Martinez A, Meunier J, Morilleau A, Delprat B, et al.
Acta Pharm Sin B
. 2024 Nov;
14(10):4345-4359.
PMID: 39525570
The aggregation of Amyloid- (A) peptides is associated with neurodegeneration in Alzheimer's disease (AD). We previously identified novel naphtalene derivatives, including the lead compound Amylovis-201, able to form thermodynamically stable...
2.
Carles A, Hoffmann M, Scheiner M, Crouzier L, Bertrand-Gaday C, Chatonnet A, et al.
CNS Neurosci Ther
. 2024 Jun;
30(6):e14814.
PMID: 38887858
Aims: Alzheimer's disease (AD) is a devastating dementia characterized by extracellular amyloid-β (Aβ) protein aggregates and intracellular tau protein deposition. Clinically available drugs mainly target acetylcholinesterase (AChE) and indirectly sustain...
3.
Crouzier L, Meunier J, Carles A, Morilleau A, Vrigneau C, Schmitt M, et al.
Phytother Res
. 2023 Nov;
38(2):694-712.
PMID: 38011416
Background And Aim: By using an in vivo phenotypic screening assay in zebrafish, we identified Convolamine, a tropane alkaloid from Convulvus plauricalis, as a positive modulator of the sigma-1 receptor...
4.
Richard E, Brun E, Korchagina J, Crouzier L, Affortit C, Alves S, et al.
Cell Death Dis
. 2023 Jun;
14(6):387.
PMID: 37386014
Wolfram syndrome (WS) is a rare neurodegenerative disorder encompassing diabetes mellitus, diabetes insipidus, optic atrophy, hearing loss (HL) as well as neurological disorders. None of the animal models of the...
5.
Lasbleiz C, Peyrel A, Tarot P, Sarniguet J, Crouzier L, Cubedo N, et al.
Redox Biol
. 2022 Nov;
58:102542.
PMID: 36442393
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons. As a consequence, ALS patients display a locomotor disorder related to muscle weakness and progressive paralysis....
6.
Crouzier L, Richard E, Diez C, Denus M, Peyrel A, Alzaeem H, et al.
Mol Ther Methods Clin Dev
. 2022 Nov;
27:295-308.
PMID: 36320410
Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic atrophy, diabetes, and neurological disorders. Currently, no treatment is available for patients. The mutated gene, , encodes an...
7.
Crouzier L, Richard E, Diez C, Alzaeem H, Denus M, Cubedo N, et al.
Hum Mol Genet
. 2022 Mar;
31(16):2711-2727.
PMID: 35325133
Wolfram syndrome (WS) is a rare genetic disease characterized by diabetes, optic atrophy and deafness. Patients die at 35 years of age, mainly from respiratory failure or dysphagia. Unfortunately, there...
8.
Crouzier L, Danese A, Yasui Y, Richard E, Lievens J, Patergnani S, et al.
Sci Transl Med
. 2022 Feb;
14(631):eabh3763.
PMID: 35138910
The Wolfram syndrome is a rare autosomal recessive disease affecting many organs with life-threatening consequences; currently, no treatment is available. The disease is caused by mutations in the gene, coding...
9.
Crouzier L, Richard E, Sourbron J, Lagae L, Maurice T, Delprat B
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34948153
Rare genetic diseases are a group of pathologies with often unmet clinical needs. Even if rare by a single genetic disease (from 1/2000 to 1/more than 1,000,000), the total number...
10.
Crouzier L, Denus M, Richard E, Tavernier A, Diez C, Cubedo N, et al.
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681705
The sigma-1 receptor (S1R) is a highly conserved transmembrane protein highly enriched in mitochondria-associated endoplasmic reticulum (ER) membranes, where it interacts with several partners involved in ER-mitochondria Ca transfer, activation...