Lucas Sagrillo-Fagundes
Overview
Explore the profile of Lucas Sagrillo-Fagundes including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
170
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Recent Articles
1.
Parameshwar P, Sagrillo-Fagundes L, Azevedo Portilho N, Pastor W, Vaillancourt C, Moraes C
Reprod Toxicol
. 2022 Jul;
112:148-159.
PMID: 35840119
Recent increases in prescriptions and illegal drug use as well as exposure to environmental contaminants during pregnancy have highlighted the critical importance of placental toxicology in understanding and identifying risks...
2.
Parameshwar P, Sagrillo-Fagundes L, Fournier C, Girard S, Vaillancourt C, Moraes C
Biomater Sci
. 2021 Oct;
9(21):7247-7256.
PMID: 34608901
The placental syncytiotrophoblast is a multinucleated layer that regulates transport between the mother and fetus. Fusion of trophoblasts is essential to form this layer, but this process can be disrupted...
3.
Sagrillo-Fagundes L, Paim T, Pretto L, Bertaco I, Zanatelli C, Vaillancourt C, et al.
J Cell Physiol
. 2021 Oct;
237(1):507-522.
PMID: 34596240
Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells....
4.
Ma Z, Sagrillo-Fagundes L, Mok S, Vaillancourt C, Moraes C
Sci Rep
. 2020 Apr;
10(1):5837.
PMID: 32246004
The syncytiotrophoblast is a multinucleated layer that plays a critical role in regulating functions of the human placenta during pregnancy. Maintaining the syncytiotrophoblast layer relies on ongoing fusion of mononuclear...
5.
Ma Z, Sagrillo-Fagundes L, Tran R, Parameshwar P, Kalashnikov N, Vaillancourt C, et al.
ACS Appl Mater Interfaces
. 2019 Nov;
11(51):47810-47821.
PMID: 31773938
The placental syncytiotrophoblast is a giant multinucleated cell that forms a tree-like structure and regulates transport between mother and baby during development. It is maintained throughout pregnancy by continuous fusion...
6.
Sagrillo-Fagundes L, Bienvenue-Pariseault J, Legembre P, Vaillancourt C
Birth Defects Res
. 2019 Feb;
111(4):197-211.
PMID: 30702213
The prototype death receptor CD95 (Fas) and its ligand, CD95L (FasL), have been thoroughly studied due to their role in immune homeostasis and elimination of infected and transformed cells. The...
7.
Sagrillo-Fagundes L, Bienvenue-Pariseault J, Vaillancourt C
PLoS One
. 2019 Jan;
14(1):e0202458.
PMID: 30629581
Melatonin has protective roles in normal cells and cytotoxic actions in cancer cells, with effects involving autophagy and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor pathways. Hypoxia/reoxygenation (H/R) induces...
8.
Sagrillo-Fagundes L, Assuncao Salustiano E, Ruano R, Markus R, Vaillancourt C
J Pineal Res
. 2018 Aug;
65(4):e12520.
PMID: 30091210
Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such as autophagy, inflammation, and apoptosis. Pathological pregnancies, such as preeclampsia, are associated with placental...
9.
Sagrillo-Fagundes L, Laurent L, Bienvenue-Pariseault J, Vaillancourt C
Methods Mol Biol
. 2017 Dec;
1710:277-283.
PMID: 29197010
Lack of blood flow and aberrant levels of oxygenation in placentas are recurrent in pregnancy diseases, such as preeclampsia. These alterations generate situations of hypoxia and hypoxia/reoxygenation (H/R) and consequent...
10.
Sagrillo-Fagundes L, Clabault H, Laurent L, Hudon-Thibeault A, Salustiano E, Fortier M, et al.
J Vis Exp
. 2016 Aug;
(113).
PMID: 27500522
This protocol describes how villous cytotrophoblast cells are isolated from placentas at term by successive enzymatic digestions, followed by density centrifugation, media gradient isolation and immunomagnetic purification. As observed in...