Lucas J Gutierrez
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Explore the profile of Lucas J Gutierrez including associated specialties, affiliations and a list of published articles.
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10
Citations
33
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Recent Articles
1.
Hudcova A, Kroutil A, Kubinova R, Garro A, Gutierrez L, Enriz D, et al.
Molecules
. 2020 Apr;
25(7).
PMID: 32290227
Neurodegenerative diseases in which the decrease of the acetylcholine is observed are growing worldwide. In the present study, a series of new arylaminopropanone derivatives with -phenylcarbamate moiety () were prepared...
2.
Lamut A, Skok Z, Barancokova M, Gutierrez L, Cruz C, Tammela P, et al.
Future Med Chem
. 2020 Feb;
12(4):277-297.
PMID: 32043377
DNA gyrase and topoisomerase IV are essential bacterial enzymes, and in the fight against bacterial resistance, they are important targets for the development of novel antibacterial drugs. Building from our...
3.
Munoz M, Gutierrez L, Delignat S, Russick J, Gomez Mejiba S, Lacroix-Desmazes S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 Jan;
1865(6):1152-1159.
PMID: 30684639
The nitrone spin trap 5,5‑dimethyl‑1‑pyrroline N‑oxide (DMPO) dampens endotoxin-induced and TLR4-driven priming of macrophages, but the mechanism remains unknown. The available information suggests a direct binding of DMPO to the...
4.
Gutierrez L, Parravicini O, Sanchez E, Rodriguez R, Cobo J, Enriz R
J Biomol Struct Dyn
. 2018 Jan;
37(1):229-246.
PMID: 29301478
We report in this work new substituted aminopyrimidine derivatives acting as inhibitors of the catalytic site of BACE1. These compounds were obtained from a molecular modeling study. The theoretical and...
5.
Parravicini O, Bogado M, Rojas S, Angelina E, Andujar S, Gutierrez L, et al.
J Mol Model
. 2017 Sep;
23(9):273.
PMID: 28866777
A series of tetrahydroisoquinolines functionalized with carbamates is reported here as highly selective ligands on the dopamine D2 receptor. These compounds were selected by means of a molecular modeling study....
6.
PArraga J, Andujar S, Rojas S, Gutierrez L, El Aouad N, Sanz M, et al.
Eur J Med Chem
. 2016 Jun;
122:27-42.
PMID: 27343851
Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson's disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl-1,2,3,7,8,8a-hexahydrocyclopenta[ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4-...
7.
Gutierrez L, Angelina E, Gyebrovszki A, Fulop L, Peruchena N, Baldoni H, et al.
J Biomol Struct Dyn
. 2016 Jan;
35(2):413-426.
PMID: 26813690
We report here two new small-size peptides acting as modulators of the β-site APP cleaving enzyme 1 (BACE1) exosite. Ac-YPYFDPL-NH2 and Ac-YPYDIPL-NH2 displayed a moderate but significant inhibitory effect on...
8.
Barrera Guisasola E, Gutierrez L, Andujar S, Angelina E, Rodriguez A, Enriz R
Curr Protein Pept Sci
. 2015 Nov;
17(2):156-68.
PMID: 26521954
The structure-based drug design has been an extremely useful technique used for searching and developing of new therapeutic agents in various biological systems. In the case of AD, this approach...
9.
Gutierrez L, Mascotti M, Kurina-Sanz M, Pungitore C, Enriz R, Giannini F
Nat Prod Commun
. 2013 Feb;
7(12):1639-44.
PMID: 23413572
Some members of a series of cinnamic acid derivatives possess promising inhibitory activities in cellular assays against fungi of the Aspergillus genus. In order to search for a possible molecular...
10.
Gutierrez L, Enriz R, Baldoni H
J Phys Chem A
. 2010 Sep;
114(37):10261-9.
PMID: 20806954
We report a molecular modeling study aimed to locate and provide the full structural characteristics of the exosite binding site of the BACE1. A three-step procedure was followed. In the...