Luca Simula
Overview
Explore the profile of Luca Simula including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
456
Followers
0
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Recent Articles
1.
Cune D, Pitasi C, Rubiola A, Jamma T, Simula L, Boucher C, et al.
Cell Death Dis
. 2025 Feb;
16(1):112.
PMID: 39971913
Autophagy, a cytoprotective mechanism in intestinal epithelial cells, plays a crucial role in maintaining intestinal homeostasis. Beyond its cell-autonomous effects, the significance of autophagy in these cells is increasingly acknowledged...
2.
Icard P, Prieto M, Coquerel A, Fournel L, Gligorov J, Noel J, et al.
Drug Resist Updat
. 2024 Nov;
78:101177.
PMID: 39612545
Immunotherapy, either alone or in combination with chemotherapy, has demonstrated limited efficacy in a variety of solid cancers. Several factors contribute to explaining primary or secondary resistance. Among them, cancer...
3.
Gonzalez-Fernandez P, Simula L, Jenni S, Jordan O, Allemann E
Int J Pharm
. 2024 Apr;
657:124139.
PMID: 38677396
Mesenchymal stem cell (MSC) therapy shows promise in regenerative medicine. For osteoarthritis (OA), MSCs delivered to the joint have a temporal window in which they can secrete growth factors and...
4.
Simula L, Fumagalli M, Vimeux L, Rajnpreht I, Icard P, Birsen G, et al.
Nat Commun
. 2024 Mar;
15(1):2203.
PMID: 38467616
The ability of CD8 T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T...
5.
Icard P, Simula L, Zahn G, Alifano M, Mycielska M
Biochim Biophys Acta Rev Cancer
. 2023 Sep;
1878(6):188987.
PMID: 37717858
Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid...
6.
Marchais M, Simula L, Phayanouvong M, Mami-Chouaib F, Bismuth G, Decroocq J, et al.
Cancer Immunol Res
. 2023 Aug;
11(11):1508-1523.
PMID: 37649096
Chimeric antigen receptor (CAR) T cells have shown promising results in the treatment of B-cell malignancies. Despite the successes, challenges remain. One of them directly involves the CAR T-cell manufacturing...
7.
Icard P, Alifano M, Simula L
Trends Endocrinol Metab
. 2023 Aug;
34(10):586-589.
PMID: 37550099
Epigenetic drugs induce ATP depletion, promoting a glycolysis-to-oxidative phosphorylation (OXPHOS) shift which sometimes favors tumor growth by promoting necroptosis over apoptosis. To restore effective apoptosis in tumors, we propose that...
8.
Icard P, Simula L, Fournel L, Leroy K, Lupo A, Damotte D, et al.
Drug Resist Updat
. 2022 Jul;
63:100852.
PMID: 35849943
NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF-1α. Moreover, chemoresistance...
9.
Simula L, Ollivier E, Icard P, Donnadieu E
Cells
. 2022 Jun;
11(11).
PMID: 35681548
Adoptive transfer of T cells genetically engineered to express chimeric antigen receptors (CAR) has demonstrated striking efficacy for the treatment of several hematological malignancies, including B-cell lymphoma, leukemia, and multiple...
10.
Simula L, Alifano M, Icard P
Cancers (Basel)
. 2022 May;
14(10).
PMID: 35626081
PI3K/AKT is one of the most frequently altered signaling pathways in human cancers, supporting the activation of many proteins sustaining cell metabolism, proliferation, and aggressiveness. Another important pathway frequently altered...