Luca Pellegrinet
Overview
Explore the profile of Luca Pellegrinet including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
998
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0
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Recent Articles
1.
Sodir N, Pellegrinet L, Kortlever R, Campos T, Kwon Y, Kim S, et al.
Nat Commun
. 2022 Nov;
13(1):6782.
PMID: 36351945
Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and...
2.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, et al.
Hepatology
. 2020 May;
73(3):1028-1044.
PMID: 32460431
Background And Aims: Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC). However, the metabolic control of these processes is not fully...
3.
Sodir N, Kortlever R, Barthet V, Campos T, Pellegrinet L, Kupczak S, et al.
Cancer Discov
. 2020 Jan;
10(4):588-607.
PMID: 31941709
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute activation of in indolent pancreatic intraepithelial neoplasm (PanIN)...
4.
Kortlever R, Sodir N, Wilson C, Burkhart D, Pellegrinet L, Swigart L, et al.
Cell
. 2017 Dec;
171(6):1301-1315.e14.
PMID: 29195074
The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRas-driven adenomas, we find that co-activation of...
5.
Kress T, Pellanda P, Pellegrinet L, Bianchi V, Nicoli P, Doni M, et al.
Cancer Res
. 2016 May;
76(12):3463-72.
PMID: 27197165
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. However, the gene expression programs that depend upon sustained MYC activity remain unknown. In this study, we...
6.
Lopez-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman A, et al.
Development
. 2014 Dec;
142(1):41-50.
PMID: 25480918
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due...
7.
Smith E, Claudinot S, Lehal R, Pellegrinet L, Barrandon Y, Radtke F
Genesis
. 2012 Apr;
50(9):700-10.
PMID: 22488965
Signaling through the Notch1 receptor is essential for the control of numerous developmental processes during embryonic life as well as in adult tissue homeostasis and disease. Since the outcome of...
8.
Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, et al.
Gastroenterology
. 2011 Jan;
140(4):1230-1240.e1-7.
PMID: 21238454
Background & Aims: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We aimed to confirm...
9.
Riccio O, van Gijn M, Bezdek A, Pellegrinet L, van Es J, Zimber-Strobl U, et al.
EMBO Rep
. 2008 Feb;
9(4):377-83.
PMID: 18274550
The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice....