Luca Giorgetti
Overview
Explore the profile of Luca Giorgetti including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
3367
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Recent Articles
1.
Cossmann J, Kos P, Varamogianni-Mamatsi V, Assenheimer D, Bischof T, Kuhn T, et al.
Nat Commun
. 2025 Feb;
16(1):1833.
PMID: 39979259
The three-dimensional folding of chromosomes is essential for nuclear functions such as DNA replication and gene regulation. The emergence of chromatin architecture is thus an important process during embryogenesis. To...
2.
Jusuf J, Grosse-Holz S, Gabriele M, Mach P, Flyamer I, Zechner C, et al.
bioRxiv
. 2025 Feb;
PMID: 39935886
3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these methods only measure 3D interaction probabilities...
3.
Iurlaro M, Masoni F, Flyamer I, Wirbelauer C, Iskar M, Burger L, et al.
Nat Genet
. 2024 Nov;
56(11):2574-2575.
PMID: 39487354
No abstract available.
4.
Iurlaro M, Masoni F, Flyamer I, Wirbelauer C, Iskar M, Burger L, et al.
Nat Genet
. 2024 May;
56(6):1203-1212.
PMID: 38816647
Catalytic activity of the imitation switch (ISWI) family of remodelers is critical for nucleosomal organization and DNA binding of certain transcription factors, including the insulator protein CTCF. Here we define...
5.
Mielczarek O, Rogers C, Zhan Y, Matheson L, Stubbington M, Schoenfelder S, et al.
Cell Rep
. 2023 Sep;
42(9):113074.
PMID: 37676766
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J)...
6.
Mach P, Giorgetti L
Curr Opin Genet Dev
. 2023 May;
80:102052.
PMID: 37257410
The spatiotemporal control of gene expression in complex multicellular organisms relies on noncoding regulatory sequences such as enhancers, which activate transcription of target genes often over large genomic distances. Despite...
7.
Mach P, Kos P, Zhan Y, Cramard J, Gaudin S, Tunnermann J, et al.
Nat Genet
. 2022 Dec;
54(12):1907-1918.
PMID: 36471076
In mammals, interactions between sequences within topologically associating domains enable control of gene expression across large genomic distances. Yet it is unknown how frequently such contacts occur, how long they...
8.
Piskadlo E, Eichenberger B, Giorgetti L, Chao J
Methods Mol Biol
. 2022 Jul;
2537:173-183.
PMID: 35895264
Visualization of single mRNA molecules in fixed cells can be achieved using single molecule fluorescent in situ hybridization (smFISH). This approach enables accurate quantification of mRNA numbers and localization at...
9.
Harmel C, Sid Ahmed S, Koch R, Tunnermann J, Distler T, Imle A, et al.
Bioinformatics
. 2022 May;
38(10):2970-2972.
PMID: 35561161
Motivation: Live-cell microscopy has become an essential tool for analyzing dynamic processes in various biological applications. Thereby, high-throughput and automated tracking analyses allow the simultaneous evaluation of large numbers of...
10.
Galupa R, Picard C, Servant N, Nora E, Zhan Y, van Bemmel J, et al.
Development
. 2022 May;
149(9).
PMID: 35502750
The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors (e.g. CTCF) underlying topologically associating domains (TADs) leads to...