Luc Demange
Overview
Explore the profile of Luc Demange including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
560
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Recent Articles
1.
Gresh N, Ongaro A, Demange L, Zagotto G, Ribaudo G
ACS Omega
. 2024 Oct;
9(41):42309-42328.
PMID: 39431064
The d(GGCGCC) palindrome is encountered in several oncogenic and retroviral sequences. In order to target it, we previously designed several oligopeptide derivatives of the mitoxantrone and ametantrone anticancer intercalators. These...
2.
Crouzet A, Lopez N, Riss Yaw B, Lepelletier Y, Demange L
Molecules
. 2024 Jun;
29(12).
PMID: 38930784
The journey of drug discovery (DD) has evolved from ancient practices to modern technology-driven approaches, with Artificial Intelligence (AI) emerging as a pivotal force in streamlining and accelerating the process....
3.
Grytsai O, Dufies M, Le Du J, Rastoin O, Goncalves L, Mateo L, et al.
ACS Med Chem Lett
. 2024 Jun;
15(6):845-856.
PMID: 38894897
CXCR1/2 biomolecules play vital roles in cancer cell proliferation, tumor inflammation, and angiogenesis, making them attractive drug targets. In clear cell renal cell carcinoma (RCC) and head and neck squamous...
4.
Pierre M, Lamaa D, Fabre M, Ronco C, Benhida R, Demange L, et al.
Med Sci (Paris)
. 2023 Dec;
39(12):958-966.
PMID: 38108727
The therapeutic management of age-related macular degeneration (AMD) is a major public health issue. One of its two late forms, neovascular AMD, is currently treated by intravitreal injections of pharmaceutical...
5.
El Mahmoudi A, Tareau A, Barreau M, Chevalier S, Hourma C, Demange L, et al.
Bioorg Med Chem Lett
. 2023 Oct;
96:129517.
PMID: 37838341
The search for new classes of antibiotics is a real concern of public health due to the emergence of multi-resistant bacteria strains. We report herein the synthesis and characterization of...
6.
Fabre M, Mateo L, Lamaa D, Baillif S, Pages G, Demange L, et al.
Molecules
. 2022 Aug;
27(16).
PMID: 36014339
Age-related macular degeneration (AMD) was described for the first time in the 1840s and is currently the leading cause of blindness for patients over 65 years in Western Countries. This...
7.
El Hage K, Ribaudo G, Lagardere L, Ongaro A, Kahn P, Demange L, et al.
J Chem Inf Model
. 2022 Jul;
62(24):6649-6666.
PMID: 35895094
GC-rich sequences are recurring motifs in oncogenes and retroviruses and could be targeted by noncovalent major-groove therapeutic ligands. We considered the palindromic sequence d(GGCGCC), and designed several oligopeptide derivatives of...
8.
Dumond A, Brachet E, Durivault J, Vial V, Puszko A, Lepelletier Y, et al.
J Exp Clin Cancer Res
. 2021 Jan;
40(1):33.
PMID: 33461580
Background: Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain...
9.
Grytsai O, Valiashko O, Penco-Campillo M, Dufies M, Hagege A, Demange L, et al.
Bioorg Chem
. 2020 Sep;
104:104271.
PMID: 32992279
Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited...
10.
Dumond A, Demange L, Pages G
Med Sci (Paris)
. 2020 May;
36(5):487-496.
PMID: 32452371
Exacerbated angiogenesis is one of the hallmarks of cancer defined by Hanahan and Weinberg. However, targeting the signaling pathway of the "Vascular Endothelial Growth Factor (VEGF)" or its receptors has...