Lu Huo
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Explore the profile of Lu Huo including associated specialties, affiliations and a list of published articles.
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15
Citations
143
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Recent Articles
1.
Hummel J, Xiao K, Yang J, Epling L, Mukai K, Ye Q, et al.
J Med Chem
. 2024 Feb;
67(4):3112-3126.
PMID: 38325398
CDK2 is a critical regulator of the cell cycle. For a variety of human cancers, the dysregulation of CDK2/cyclin E1 can lead to tumor growth and proliferation. Historically, early efforts...
2.
Newton A, McCann L, Huo L, Liu A
Metabolites
. 2023 Apr;
13(4).
PMID: 37110158
The kynurenine pathway (KP) is the primary route for the catabolism of the essential amino acid tryptophan. The central KP metabolites are neurologically active molecules or biosynthetic precursors to critical...
3.
Sokolsky A, Winterton S, Kennedy K, Drake K, Stump K, Huo L, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1797-1804.
PMID: 36385925
A series of exceptionally selective CDK2 inhibitors are described. Starting from an HTS hit, we successfully scaffold hopped to a 5,7-dihydro-6-pyrrolo[2,3-]pyrimidin-6-one core structure, which imparted a promising initial selectivity within...
4.
Huo L, Qi Y, Zhao S
BMC Ophthalmol
. 2021 Nov;
21(1):403.
PMID: 34814873
Background: Infancy is the of a child's visual development. Refractive errors, especially myopia, are a common vision disorder. Thus, the purpose of this study was to explore refractive errors and...
5.
Huo L, Hu X, Xiao Q, Gu Y, Chu X, Jiang L
Magn Reson Imaging
. 2021 Jun;
82:31-41.
PMID: 34147598
Purpose: Segmentation of the whole breast and fibroglandular tissue (FGT) is important for quantitatively analyzing the breast cancer risk in the dynamic contrast-enhanced magnetic resonance (DCE-MR) images. The purpose of...
6.
Single-cell multi-omics sequencing: application trends, COVID-19, data analysis issues and prospects
Huo L, Li J, Chen L, Yu Z, Hutvagner G, Li J
Brief Bioinform
. 2021 Jun;
22(6).
PMID: 34111889
Single-cell sequencing is a biotechnology to sequence one layer of genomic information for individual cells in a tissue sample. For example, single-cell DNA sequencing is to sequence the DNA from...
7.
Shao D, Zhu X, Sun W, Huo L, Chen W, Wang H, et al.
Mol Med Rep
. 2017 Jul;
16(4):3737-3744.
PMID: 28731161
The purpose of the present study was to investigate the molecular mechanisms of myotonic dystrophy (DM) 1 and 2 cataracts using bioinformatics methods. A microarray dataset (E‑MEXP‑3365) downloaded from the...
8.
Huo L, Liu J, Dearing M, Szklarz G, Halpert J, Wilderman P
Biochemistry
. 2017 Apr;
56(16):2238-2246.
PMID: 28375626
On the basis of recent functional and structural characterization of cytochromes P450 2B from the desert woodrat (Neotoma lepida), the 7-alkoxycoumarin and 7-alkoxy-4-(trifluoromethyl)coumarin O-dealkylation profiles of CYP2B35 and CYP2B37 were...
9.
Geng J, Huo L, Liu A
J Inorg Biochem
. 2016 Dec;
167:60-67.
PMID: 27907864
The diheme enzyme MauG utilizes HO to perform oxidative posttranslational modification on a protein substrate. A bis-Fe(IV) species of MauG was previously identified as a key intermediate in this reaction....
10.
Shah M, Liu J, Huo L, Zhang Q, Dearing M, Wilderman P, et al.
Mol Pharmacol
. 2016 Jan;
89(4):435-45.
PMID: 26826176
Crystal structures of CYP2B35 and CYP2B37 from the desert woodrat were solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI). The closed conformation of CYP2B35 contained two molecules of 4-CPI within the active...