Lowri E Cochlin
Overview
Explore the profile of Lowri E Cochlin including associated specialties, affiliations and a list of published articles.
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17
Citations
1040
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Recent Articles
1.
Murray A, Knight N, Cole M, Cochlin L, Carter E, Tchabanenko K, et al.
FASEB J
. 2016 Aug;
30(12):4021-4032.
PMID: 27528626
Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketones...
2.
Dass S, Holloway C, Cochlin L, Rider O, Mahmod M, Robson M, et al.
Circ Heart Fail
. 2015 Sep;
8(6):1088-93.
PMID: 26333351
Background: Whether the myocardium in nonischemic heart failure experiences oxygen limitation remains a long-standing controversy. We addressed this question in patients with dilated cardiomyopathy (DCM) using a dual approach. First,...
3.
Dass S, Cochlin L, Suttie J, Holloway C, Rider O, Carden L, et al.
Eur Heart J
. 2015 May;
36(24):1547-54.
PMID: 25990345
Aims: Hypertrophic cardiomyopathy (HCM) is the commonest cause of sudden cardiac death in the young, with an excess of exercise-related deaths. The HCM sarcomere mutations increase the energy cost of...
4.
Holloway C, Murray A, Mitchell K, Martin D, Johnson A, Cochlin L, et al.
High Alt Med Biol
. 2014 Mar;
15(4):459-67.
PMID: 24661196
Exposure to high altitude is associated with sustained, but reversible, changes in cardiac mass, diastolic function, and high-energy phosphate metabolism. Whilst the underlying mechanisms remain elusive, tissue hypoxia increases generation...
5.
Emmanuel Y, Cochlin L, Tyler D, de Jager C, Smith A, Clarke K
Brain Behav
. 2013 Mar;
3(2):134-44.
PMID: 23533158
Neuronal glucose uptake was thought to be independent of insulin, being facilitated by glucose transporters GLUT1 and GLUT3, which do not require insulin signaling. However, it is now known that...
6.
Holloway C, Dass S, Suttie J, Rider O, Cox P, Cochlin L, et al.
Heart
. 2012 Jun;
98(14):1083-90.
PMID: 22739638
Objective: To determine the effects of short-term exercise training on cardiac function and metabolism during rest and physical exercise in patients with heart failure from dilated cardiomyopathy (DCM). Design: Patients...
7.
Clarke K, Tchabanenko K, Pawlosky R, Carter E, Knight N, Murray A, et al.
Regul Toxicol Pharmacol
. 2012 Apr;
63(2):196-208.
PMID: 22504461
(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing,...
8.
Schroeder M, Atherton H, Dodd M, Lee P, Cochlin L, Radda G, et al.
Circ Cardiovasc Imaging
. 2012 Jan;
5(2):201-9.
PMID: 22238215
Background: Carnitine acetyltransferase catalyzes the reversible conversion of acetyl-coenzyme A (CoA) into acetylcarnitine. The aim of this study was to use the metabolic tracer hyperpolarized [2-(13)C]pyruvate with magnetic resonance spectroscopy...
9.
Murray A, Knight N, Little S, Cochlin L, Clements M, Clarke K
Nutr Metab (Lond)
. 2011 Aug;
8:55.
PMID: 21806803
Short-term consumption of a high-fat diet impairs exercise capacity in both rats and humans, and increases expression of the mitochondrial uncoupling protein, UCP3, in rodent cardiac and skeletal muscle via...
10.
Cole M, Murray A, Cochlin L, Heather L, McAleese S, Knight N, et al.
Basic Res Cardiol
. 2011 Feb;
106(3):447-57.
PMID: 21318295
Elevated levels of cardiac mitochondrial uncoupling protein 3 (UCP3) and decreased cardiac efficiency (hydraulic power/oxygen consumption) with abnormal cardiac function occur in obese, diabetic mice. To determine whether cardiac mitochondrial...