Helen J Atherton
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Explore the profile of Helen J Atherton including associated specialties, affiliations and a list of published articles.
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19
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1029
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Recent Articles
1.
Murray A, Knight N, Cole M, Cochlin L, Carter E, Tchabanenko K, et al.
FASEB J
. 2016 Aug;
30(12):4021-4032.
PMID: 27528626
Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketones...
2.
Dodd M, Atherton H, Carr C, Stuckey D, West J, Griffin J, et al.
Circ Cardiovasc Imaging
. 2014 Sep;
7(6):895-904.
PMID: 25201905
Background: Myocardial infarction (MI) is one of the leading causes of heart failure. An increasing body of evidence links alterations in cardiac metabolism and mitochondrial function with the progression of...
3.
Heather L, Pates K, Atherton H, Cole M, Ball D, Evans R, et al.
Circ Heart Fail
. 2013 Aug;
6(5):1058-66.
PMID: 23940308
Background: Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away...
4.
Carobbio S, Hagen R, Lelliott C, Slawik M, Medina-Gomez G, Tan C, et al.
Diabetes
. 2013 Aug;
62(11):3697-708.
PMID: 23919961
The epidemic of obesity imposes unprecedented challenges on human adipose tissue (WAT) storage capacity that may benefit from adaptive mechanisms to maintain adipocyte functionality. Here, we demonstrate that changes in...
5.
Dodd M, Ball D, Schroeder M, Le Page L, Atherton H, Heather L, et al.
Cardiovasc Res
. 2012 May;
95(1):69-76.
PMID: 22593200
Aims: The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in...
6.
Schroeder M, Atherton H, Dodd M, Lee P, Cochlin L, Radda G, et al.
Circ Cardiovasc Imaging
. 2012 Jan;
5(2):201-9.
PMID: 22238215
Background: Carnitine acetyltransferase catalyzes the reversible conversion of acetyl-coenzyme A (CoA) into acetylcarnitine. The aim of this study was to use the metabolic tracer hyperpolarized [2-(13)C]pyruvate with magnetic resonance spectroscopy...
7.
Griffin J, Atherton H, Steinbeck C, Salek R
BMC Res Notes
. 2011 Aug;
4:272.
PMID: 21801423
Background: Metabolomics is a rapidly developing functional genomic tool that has a wide range of applications in diverse fields in biology and medicine. However, unlike transcriptomics and proteomics there is...
8.
Atherton H, Dodd M, Heather L, Schroeder M, Griffin J, Radda G, et al.
Circulation
. 2011 May;
123(22):2552-61.
PMID: 21606392
Background: Hyperthyroidism increases heart rate, contractility, cardiac output, and metabolic rate. It is also accompanied by alterations in the regulation of cardiac substrate use. Specifically, hyperthyroidism increases the ex vivo...
9.
Schroeder M, Atherton H, Heather L, Griffin J, Clarke K, Radda G, et al.
NMR Biomed
. 2011 Mar;
24(8):980-987.
PMID: 21387444
Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation...
10.
Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS
Atherton H, Schroeder M, Dodd M, Heather L, Carter E, Cochlin L, et al.
NMR Biomed
. 2010 Aug;
24(2):201-208.
PMID: 20799252
Many diseases of the heart are characterised by changes in substrate utilisation, which is regulated in part by the activity of the enzyme pyruvate dehydrogenase (PDH). Consequently, there is much...