Louise McCann
Overview
Explore the profile of Louise McCann including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1523
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Recent Articles
1.
Dikalova A, Bikineyeva A, Budzyn K, Nazarewicz R, McCann L, Lewis W, et al.
Circ Res
. 2010 May;
107(1):106-16.
PMID: 20448215
Rationale: Superoxide (O2(-) ) has been implicated in the pathogenesis of many human diseases including hypertension; however, commonly used antioxidants have proven ineffective in clinical trials. It is possible that...
2.
Gongora M, Qin Z, Laude K, Kim H, McCann L, Folz J, et al.
Hypertension
. 2006 Jul;
48(3):473-81.
PMID: 16864745
We previously found that angiotensin II-induced hypertension increases vascular extracellular superoxide dismutase (ecSOD), and proposed that this is a compensatory mechanism that blunts the hypertensive response and preserves endothelium-dependent vasodilatation....
3.
Mueller C, Widder J, McNally J, McCann L, Jones D, Harrison D
Circ Res
. 2005 Aug;
97(7):637-44.
PMID: 16123331
Glutathione (GSH) is the major source of intracellular sulfhydryl groups. Oxidized GSH (GSSG) can be recycled to GSH by the GSH reductase or exported from the cell. The mechanism by...
4.
Laude K, Cai H, Fink B, Hoch N, Weber D, McCann L, et al.
Am J Physiol Heart Circ Physiol
. 2004 Oct;
288(1):H7-12.
PMID: 15471976
Protein levels and polymorphisms of p22(phox) have been suggested to modulate vascular NAD(P)H oxidase activity and vascular production of reactive oxygen species (ROS). We sought to determine whether increasing p22(phox)...
5.
Fink B, Laude K, McCann L, Doughan A, Harrison D, Dikalov S
Am J Physiol Cell Physiol
. 2004 Aug;
287(4):C895-902.
PMID: 15306539
Recently, it was demonstrated that superoxide oxidizes dihydroethidium to a specific fluorescent product (oxyethidium) that differs from ethidium by the presence of an additional oxygen atom in its molecular structure....
6.
Landmesser U, Dikalov S, Price S, McCann L, Fukai T, Holland S, et al.
J Clin Invest
. 2003 Apr;
111(8):1201-9.
PMID: 12697739
Tetrahydrobiopterin is a critical cofactor for the NO synthases, and in its absence these enzymes become "uncoupled," producing reactive oxygen species (ROSs) rather than NO. In aortas of mice with...
7.
Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training
Davis M, Cai H, McCann L, Fukai T, Harrison D
Am J Physiol Heart Circ Physiol
. 2003 Feb;
284(4):H1449-53.
PMID: 12595302
We have shown that c-Src plays a role in shear stress stimulation of endothelial nitric oxide synthase (eNOS) expression in cultured cells. To examine the role of c-Src in vivo,...
8.
Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, et al.
Hypertension
. 2002 Oct;
40(4):511-5.
PMID: 12364355
Hypertension caused by angiotensin II is dependent on vascular superoxide (O2*-) production. The nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase is a major source of vascular O2*- and is activated by...
9.
Hink H, Santanam N, Dikalov S, McCann L, Nguyen A, Parthasarathy S, et al.
Arterioscler Thromb Vasc Biol
. 2002 Sep;
22(9):1402-8.
PMID: 12231557
Objective: The cytosolic form of Cu/Zn-containing superoxide dismutase (SOD1) has peroxidase activity, with H2O2 used as a substrate to oxidize other molecules. We examined peroxidase properties of the extracellular form...