Louise M Topping
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Explore the profile of Louise M Topping including associated specialties, affiliations and a list of published articles.
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9
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86
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Recent Articles
1.
Ogbechi J, Wright H, Balint S, Topping L, Kristina Z, Huang Y, et al.
J Autoimmun
. 2023 May;
138:103031.
PMID: 37229811
The aim of this study was to assess the L-type amino acid transporter-1 (LAT1) as a possible therapeutic target for rheumatoid arthritis (RA). Synovial LAT1 expression in RA was monitored...
2.
Lavi Y, Kogan N, Topping L, Liu C, McCann F, Williams R, et al.
J Med Chem
. 2023 Apr;
66(8):5536-5549.
PMID: 37057997
There is growing interest in non-psychoactive phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), and cannabichromene, as potential leads for novel therapeutic agents. In this study, we report on the development of...
3.
Ogbechi J, Huang Y, Clanchy F, Pantazi E, Topping L, Darlington L, et al.
Front Immunol
. 2022 Nov;
13:1001956.
PMID: 36389710
Many invasive micro-organisms produce 'quorum sensor' molecules which regulate colony expansion and may modulate host immune responses. We have examined the ability of Quorum Sensor (PQS) to influence cytokine expression...
4.
Topping L, Romero-Castillo L, Urbonaviciute V, Bolinsson H, Clanchy F, Holmdahl R, et al.
Front Immunol
. 2022 Jun;
13:892251.
PMID: 35769487
Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models,...
5.
Kogan N, Lavi Y, Topping L, Williams R, McCann F, Yekhtin Z, et al.
Molecules
. 2021 Sep;
26(18).
PMID: 34577072
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG...
6.
Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis
Huang Y, Tseng W, Clanchy F, Topping L, Ogbechi J, McNamee K, et al.
Proc Natl Acad Sci U S A
. 2021 May;
118(19).
PMID: 33941676
Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and,...
7.
Gigout A, Harazin D, Topping L, Merciris D, Lindemann S, Brenneis C, et al.
Arthritis Res Ther
. 2021 Apr;
23(1):113.
PMID: 33853645
Background: Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be...
8.
Topping L, Thomas B, Rhys H, Tremoleda J, Foster M, Seed M, et al.
Front Immunol
. 2020 Mar;
11:10.
PMID: 32117219
The targeted delivery of therapies to diseased tissues offers a safe opportunity to achieve optimal efficacy while limiting systemic exposure. These considerations apply to many disease indications but are especially...
9.
Ogbechi J, Clanchy F, Huang Y, Topping L, Stone T, Williams R
Exp Gerontol
. 2019 Dec;
131:110820.
PMID: 31884118
The IDO/kynurenine pathway is now established as a major regulator of immune system function. The initial enzyme, indoleamine 2,3-dioxygenase (IDO1) is induced by IFNγ, while tryptophan-2,3-dioxygenase (TDO) is induced by...