Louise E Tailford
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Explore the profile of Louise E Tailford including associated specialties, affiliations and a list of published articles.
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22
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1203
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Recent Articles
1.
Monaco S, Tailford L, Bell A, Wallace M, Juge N, Angulo J
Bioorg Chem
. 2024 Nov;
153:107906.
PMID: 39515130
RgNanH is an intramolecular trans-sialidase expressed by the human gut symbiont Ruminococcus gnavus, to utilise intestinal sialylated mucin glycan epitopes. Its catalytic domain, belonging to glycoside hydrolase GH33 family, cleaves...
2.
Owen C, Tailford L, Monaco S, Suligoj T, Vaux L, Lallement R, et al.
Nat Commun
. 2017 Dec;
8(1):2196.
PMID: 29259165
Ruminococcus gnavus is a human gut symbiont wherein the ability to degrade mucins is mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic domain and a sialic acid-binding...
3.
Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein-Ligand Contacts
Monaco S, Tailford L, Juge N, Angulo J
Angew Chem Int Ed Engl
. 2017 Oct;
56(48):15289-15293.
PMID: 28977722
Saturation transfer difference (STD) NMR spectroscopy is extensively used to obtain epitope maps of ligands binding to protein receptors, thereby revealing structural details of the interaction, which is key to...
4.
Monestier M, Latousakis D, Bell A, Tribolo S, Tailford L, Colquhoun I, et al.
Carbohydr Res
. 2017 Aug;
451:110-117.
PMID: 28851488
Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases). A facile one-pot two-enzyme approach has been established for the synthesis of 2,7-anhydro-sialic acid derivatives including...
5.
Crost E, Tailford L, Monestier M, Swarbreck D, Henrissat B, Crossman L, et al.
Gut Microbes
. 2016 May;
7(4):302-312.
PMID: 27223845
We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins....
6.
Tailford L, Owen C, Walshaw J, Crost E, Hardy-Goddard J, Le Gall G, et al.
Nat Commun
. 2015 Jul;
6:7624.
PMID: 26154892
The gastrointestinal mucus layer is colonized by a dense community of microbes catabolizing dietary and host carbohydrates during their expansion in the gut. Alterations in mucosal carbohydrate availability impact on...
7.
Tailford L, Crost E, Kavanaugh D, Juge N
Front Genet
. 2015 Apr;
6:81.
PMID: 25852737
The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In particular, some gut bacteria have the...
8.
Etzold S, Kober O, MacKenzie D, Tailford L, Gunning A, Walshaw J, et al.
Environ Microbiol
. 2013 Dec;
16(3):888-903.
PMID: 24373178
The mucus layer covering the gastrointestinal (GI) epithelium is critical in selecting and maintaining homeostatic interactions with our gut bacteria. However, the underpinning mechanisms of these interactions are not understood....
9.
Crost E, Tailford L, Le Gall G, Fons M, Henrissat B, Juge N
PLoS One
. 2013 Nov;
8(10):e76341.
PMID: 24204617
Commensal bacteria often have an especially rich source of glycan-degrading enzymes which allow them to utilize undigested carbohydrates from the food or the host. The species Ruminococcus gnavus is present...
10.
Gunning A, Kirby A, Fuell C, Pin C, Tailford L, Juge N
FASEB J
. 2013 Mar;
27(6):2342-54.
PMID: 23493619
Mucins are the main components of the gastrointestinal mucus layer. Mucin glycosylation is critical to most intermolecular and intercellular interactions. However, due to the highly complex and heterogeneous mucin glycan...