Lou F M H de Leij
Overview
Explore the profile of Lou F M H de Leij including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
596
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Recent Articles
1.
van der Gun B, Melchers L, Ruiters M, de Leij L, McLaughlin P, Rots M
Carcinogenesis
. 2010 Sep;
31(11):1913-21.
PMID: 20837599
The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a...
2.
Trzpis M, Bremer E, McLaughlin P, de Leij L, Harmsen M
Front Biosci
. 2008 May;
13:5050-5.
PMID: 18508569
Embryonic development is one of the most complex biological phenomena that involves the appropriate expression and synchronized interactions of a plethora of proteins, including cell adhesion molecules (CAMs). Many members...
3.
Bremer E, de Bruyn M, Samplonius D, Bijma T, ten Cate B, de Leij L, et al.
J Mol Med (Berl)
. 2008 May;
86(8):909-24.
PMID: 18504532
Previously, we have shown that epidermal growth factor receptor (EGFR)-selective delivery of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), by genetic fusion to antibody fragment scFv425, enhances the tumor-selective pro-apoptotic...
4.
van der Gun B, Wasserkort R, Monami A, Jeltsch A, Rasko T, Slaska-Kiss K, et al.
Int J Cancer
. 2008 Apr;
123(2):484-489.
PMID: 18398839
The epithelial cell adhesion molecule (EpCAM) is expressed at high levels on the surface of most carcinoma cells. SiRNA silencing of EpCAM expression leads to reduced metastatic potential of tumor...
5.
van der Gun B, Monami A, Laarmann S, Rasko T, Slaska-Kiss K, Weinhold E, et al.
J Control Release
. 2007 Sep;
123(3):228-38.
PMID: 17884225
Cationic liposomal compounds are widely used to introduce DNA and siRNA into viable cells, but none of these compounds are also capable of introducing proteins. Here we describe the use...
6.
Kosterink J, McLaughlin P, Lub-de Hooge M, Hendrikse H, van Zanten J, van Garderen E, et al.
J Immunol
. 2007 Jul;
179(2):1362-8.
PMID: 17617629
The human pancarcinoma-associated epithelial cell adhesion molecule (EpCAM) (EGP-2, CO17-1A) is a well-known target for carcinoma-directed immunotherapy. Mouse-derived mAbs directed to EpCAM have been used to treat colon carcinoma patients...
7.
Stel A, ten Cate B, Jacobs S, Kok J, Spierings D, Dondorff M, et al.
J Immunol
. 2007 Feb;
178(4):2287-95.
PMID: 17277134
Ab binding to CD20 has been shown to induce apoptosis in B cells. In this study, we demonstrate that rituximab sensitizes lymphoma B cells to Fas-induced apoptosis in a caspase-8-dependent...
8.
Boomker J, Verschuuren E, Brinker M, de Leij L, The T, Harmsen M
J Infect Dis
. 2006 May;
193(11):1552-6.
PMID: 16652284
Targeting viral proteins early during infection may limit exacerbation of human cytomegalovirus infection. The viral chemokine-receptor homologue US28 interferes with leukocyte trafficking and, possibly, viral replication. Because US28 molecules are...
9.
Warner J, Bruin E, Hannig H, Hellenkamp F, Horning A, Mittmann K, et al.
Transfusion
. 2006 Apr;
46(4):554-61.
PMID: 16584431
Background: Human mitochondrial DNA (mtDNA) polymorphisms can be used to detect allogeneic transfused platelets. To increase the number of informative polymorphisms we investigated three hypervariable regions (HVR1, HVR2, and HVR3)...
10.
Boomker J, The T, de Leij L, Harmsen M
Virus Res
. 2006 Feb;
118(1-2):196-200.
PMID: 16448715
The activation of the major immediate-early promoter (MIEP) is a key event in the cytomegalovirus replication cycle and is dependent on cellular transcription factors which are partially activated by viral...