Lothar Eggeling
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Explore the profile of Lothar Eggeling including associated specialties, affiliations and a list of published articles.
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86
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2658
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Recent Articles
1.
Kranz A, Polen T, Kotulla C, Arndt A, Bosco G, Bussmann M, et al.
Sci Data
. 2022 Oct;
9(1):594.
PMID: 36182956
Corynebacterium glutamicum is the major host for the industrial production of amino acids and has become one of the best studied model organisms in microbial biotechnology. Rational strain construction has...
2.
Krumbach K, Sonntag C, Eggeling L, Marienhagen J
ACS Synth Biol
. 2019 Dec;
8(12):2726-2734.
PMID: 31790583
Against the background of a growing demand for the implementation of environmentally friendly production processes, microorganisms are engineered for the large-scale biosynthesis of chemicals, fuels, or food and feed additives...
3.
Jankute M, Alderwick L, Moorey A, Joe M, Gurcha S, Eggeling L, et al.
Cell Surf
. 2018 Jul;
2:38-53.
PMID: 30046665
The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key cell wall components of the , which include Corynebacteria, Norcadia and Mycobacteria. Both AG and LAM contain elaborate arabinan domains...
4.
Alderwick L, Birch H, Krumbach K, Bott M, Eggeling L, Besra G
Cell Surf
. 2018 Jul;
1:2-14.
PMID: 29998212
Arabinogalactan (AG) is an essential structural macromolecule present in the cell wall of , serving to connect peptidoglycan with the outer mycolic acid layer. The D-arabinan segment is a highly...
5.
Bott M, Eggeling L
Adv Biochem Eng Biotechnol
. 2016 Nov;
159:227-254.
PMID: 27872965
The implementation of a knowledge-based bioeconomy requires the rapid development of highly efficient microbial production strains that are able to convert renewable carbon sources to value-added products, such as bulk...
6.
Eggeling L
Adv Biochem Eng Biotechnol
. 2016 Nov;
159:199-225.
PMID: 27832297
Microbes are talented catalysts to synthesize valuable small molecules in their cytosol. However, to make full use of their skills - and that of metabolic engineers - the export of...
7.
Hochheim J, Kranz A, Krumbach K, Sokolowsky S, Eggeling L, Noack S, et al.
Biotechnol Lett
. 2016 Oct;
39(2):283-288.
PMID: 27783176
Objectives: To explore systemic effects of mutations in the UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase (MurE) of Corynebacterium glutamicum, that leads to extracellular L-lysine accumulation by this bacterium. Results: The analysis of a...
8.
Radek A, Muller M, Gatgens J, Eggeling L, Krumbach K, Marienhagen J, et al.
J Biotechnol
. 2016 Jun;
231:160-166.
PMID: 27297548
Wild-type Corynebacterium glutamicum has no endogenous metabolic activity for utilizing the lignocellulosic pentose d-xylose for cell growth. Therefore, two different engineering approaches have been pursued resulting in platform strains harbouring...
9.
Eggeling L, Bott M
Appl Microbiol Biotechnol
. 2015 Mar;
99(8):3387-94.
PMID: 25761623
L-lysine is made in an exceptional large quantity of currently 2,200,000 tons/year and belongs therefore to one of the leading biotechnological products. Production is done almost exclusively with mutants of...
10.
Eggeling L, Bott M, Marienhagen J
Curr Opin Biotechnol
. 2015 Jan;
35:30-6.
PMID: 25578902
Biosensors offer exciting possibilities for improving cells or enzymes as biocatalysts for the synthesis of small molecules. We here review recent progress in the development and the screening applications of...