Loryn Holokai
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Explore the profile of Loryn Holokai including associated specialties, affiliations and a list of published articles.
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11
Citations
338
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Recent Articles
1.
Haag S, Xie S, Eidenschenk C, Fortin J, Callow M, Costa M, et al.
Nat Genet
. 2024 Oct;
56(11):2493-2505.
PMID: 39443811
Macrophages exhibit remarkable functional plasticity, a requirement for their central role in tissue homeostasis. During chronic inflammation, macrophages acquire sustained inflammatory 'states' that contribute to disease, but there is limited...
2.
Havnar C, Holokai L, Ichikawa R, Chen W, Scherl A, Shamir E
J Histotechnol
. 2024 Sep;
48(1):46-57.
PMID: 39234931
Organoids are tissue models derived from human or animal primary tissues or stem cells that allow for studying three-dimensional (3D) tissue biology, toxicity testing, biomarker evaluation, and assessment of compound...
3.
Kschonsak Y, Gao X, Miller S, Hwang S, Marei H, Wu P, et al.
Cell Chem Biol
. 2023 Dec;
31(6):1176-1187.e10.
PMID: 38056465
Selective and precise activation of signaling transduction cascades is key for cellular reprogramming and tissue regeneration. However, the development of small- or large-molecule agonists for many signaling pathways has remained...
4.
Holokai L, Chakrabarti J, Lundy J, Croagh D, Adhikary P, Richards S, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33348809
: Pancreatic ductal adenocarcinoma (PDAC) has the lowest five-year survival rate of all cancers in the United States. Programmed death 1 receptor (PD-1)-programmed death ligand 1 (PD-L1) immune checkpoint inhibition...
5.
Chakrabarti J, Dua-Awereh M, Holokai L, Zavros Y
Curr Top Microbiol Immunol
. 2020 Sep;
430:55-75.
PMID: 32889597
One of the major discoveries in stem cell research in the past decade embraces the development of "organs in a dish," also known as "organoids." Organoids are three-dimensional cellular structures...
6.
Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins J, Sundaram N, et al.
PLoS Pathog
. 2019 Feb;
15(1):e1007468.
PMID: 30703170
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response...
7.
Chakrabarti J, Holokai L, Syu L, Steele N, Chang J, Wang J, et al.
Oncotarget
. 2019 Jan;
9(100):37439-37457.
PMID: 30647844
Tumor cells expressing programmed cell death ligand 1 (PD-L1) interact with PD-1 on CD8+ cytotoxic T lymphocytes (CTLs) to inhibit CTL effector function. In gastric cancer, the mechanism regulating PD-L1...
8.
Steele N, Chakrabarti J, Wang J, Biesiada J, Holokai L, Chang J, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Dec;
7(1):161-184.
PMID: 30522949
Background & Aims: Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the tumor response...
9.
Chakrabarti J, Holokai L, Syu L, Steele N, Chang J, Dlugosz A, et al.
Methods Mol Biol
. 2018 Jul;
1817:157-168.
PMID: 29959712
The interaction between the receptor, programmed cell death protein 1 (PD-1) and ligand, programmed cell death 1 (PD-L1) is known to inhibit CD8+ cytotoxic T lymphocyte proliferation, survival, and effector...
10.
Teal E, Bertaux-Skeirik N, Chakrabarti J, Holokai L, Zavros Y
Methods Mol Biol
. 2018 Jul;
1817:145-155.
PMID: 29959711
Organoid cultures generated from gastrointestinal tissues have been an invaluable advancement for in vitro studies of physiological function and disease. Here we present a comprehensive protocol for the establishment and...