Lorraine Schofield
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Explore the profile of Lorraine Schofield including associated specialties, affiliations and a list of published articles.
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15
Citations
305
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Recent Articles
1.
Baggett B, Murphy K, Sengun E, Mi E, Cao Y, Turan N, et al.
Elife
. 2023 May;
12.
PMID: 37204302
Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells...
2.
Morrissey P, Murphy K, Daley J, Schofield L, Turan N, Arunachalam K, et al.
Am J Physiol Heart Circ Physiol
. 2017 Feb;
312(5):H959-H967.
PMID: 28213402
The incidence of both myocardial infarction (MI) and sudden cardiac death increases with age. Here, we describe the development of a minimally invasive large animal model of MI that can...
3.
Lau E, Kossidas K, Kim T, Kunitomo Y, Ziv O, Song Z, et al.
PLoS One
. 2015 Jul;
10(7):e0132198.
PMID: 26131559
No abstract available.
4.
Lau E, Kossidas K, Kim T, Kunitomo Y, Ziv O, Song Z, et al.
PLoS One
. 2015 May;
10(5):e0122754.
PMID: 25970695
Background: Remodeling of cardiac repolarizing currents, such as the downregulation of slowly activating K+ channels (IKs), could underlie ventricular fibrillation (VF) in heart failure (HF). We evaluated the role of...
5.
Ziv O, Schofield L, Lau E, Chaves L, Patel D, Jeng P, et al.
Am J Physiol Heart Circ Physiol
. 2012 Mar;
302(11):H2321-30.
PMID: 22447944
Ventricular arrhythmias in the setting of a healed myocardial infarction have been studied to a much lesser degree than acute and subacute infarction, due to the pericardial scarring, which results...
6.
Cooper L, Odening K, Hwang M, Chaves L, Schofield L, Taylor C, et al.
Am J Physiol Heart Circ Physiol
. 2012 Feb;
302(8):H1625-35.
PMID: 22307668
Aging increases the risk for arrhythmias and sudden cardiac death (SCD). We aimed at elucidating aging-related electrical, functional, and structural changes in the heart and vasculature that account for this...
7.
Odening K, Choi B, Liu G, Hartmann K, Ziv O, Chaves L, et al.
Heart Rhythm
. 2012 Jan;
9(5):823-32.
PMID: 22245795
Background: Postpubertal women with inherited long QT syndrome type 2 (LQT2) are at increased risk for polymorphic ventricular tachycardia (pVT) and sudden cardiac death (SCD), particularly during the postpartum period....
8.
Odening K, Kirk M, Brunner M, Ziv O, Lorvidhaya P, Liu G, et al.
Am J Physiol Heart Circ Physiol
. 2010 Jun;
299(3):H643-55.
PMID: 20581090
We have generated transgenic rabbits lacking cardiac slow delayed-rectifier K(+) current [I(Ks); long QT syndrome type 1 (LQT1)] or rapidly activating delayed-rectifier K(+) current [I(Kr); long QT syndrome type 2...
9.
Johnson L, Schofield L, Donahay T, Bouchard M, Poppas A, Haubner R
JACC Cardiovasc Imaging
. 2009 Feb;
1(4):500-10.
PMID: 19198663
Objectives: Our aim was to image angiogenesis produced by endomyocardial injection of phVEGF165 in a swine model of hibernating myocardium using [123I]Gluco-arginine-glycine-aspartic acid (RGD) targeting the alphavbeta3 integrins. Background: A...
10.
Odening K, Hyder O, Chaves L, Schofield L, Brunner M, Kirk M, et al.
Am J Physiol Heart Circ Physiol
. 2008 Oct;
295(6):H2264-72.
PMID: 18835916
Anesthetic agents prolong cardiac repolarization by blocking ion currents. However, the clinical relevance of this blockade in subjects with reduced repolarization reserve is unknown. We have generated transgenic long QT...