Lorraine M Posobiec
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Explore the profile of Lorraine M Posobiec including associated specialties, affiliations and a list of published articles.
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10
Citations
45
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Recent Articles
1.
Fishman C, Caverly Rae J, Posobiec L, Laffan S, Lerman S, Pearson N, et al.
Antimicrob Agents Chemother
. 2022 Oct;
66(11):e0048322.
PMID: 36255258
Fluoroquinolone use in children is limited due to its potential toxicity and negative effects on skeletal development, but the actual effects/risks of fluoroquinolones on bone growth and the mechanisms behind...
2.
Posobiec L, Chapman S, Murzyn S, Rendemonti J, Stanislaus D, Romach E
Birth Defects Res
. 2021 Aug;
113(16):1190-1197.
PMID: 34453500
Background: An in vitro rat whole embryo culture study investigated whether direct exposure to dolutegravir (Tivicay ) during the critical period for neural tube development would result in abnormal development....
3.
Stokes A, Franklin K, Fisher D, Posobiec L, Binazon O, Tripathi N, et al.
Int J Toxicol
. 2021 Feb;
40(2):125-142.
PMID: 33517807
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older adults. One of GSK's candidate vaccines...
4.
Posobiec L, Laffan S
Birth Defects Res
. 2020 Dec;
113(5):409-426.
PMID: 33314670
Objectives: Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains...
5.
Stanislaus D, Posobiec L, Laffan S, Solomon H, Ziejewski M, Romach E
Birth Defects Res
. 2019 Dec;
112(3):245-261.
PMID: 31859466
The success of new antiretroviral medicines for HIV resulted in a change to guidelines of standard therapy where continuation of antiretroviral therapy is recommended to maintain the low viral load...
6.
Pero J, Matthews J, Behm D, Brnardic E, Brooks C, Budzik B, et al.
J Med Chem
. 2018 Dec;
61(24):11209-11220.
PMID: 30500190
Pulmonary edema is a common ailment of heart failure patients and has remained an unmet medical need due to dose-limiting side effects associated with current treatments. Preclinical studies in rodents...
7.
Laffan S, Posobiec L, Uhl J, Vidal J
Birth Defects Res
. 2017 Dec;
110(3):163-189.
PMID: 29243395
The postnatal development of the female reproductive system in laboratory animals and humans is reviewed. To enable a meaningful species comparison of the developing female reproductive system, common definitions of...
8.
Posobiec L, Cox E, Solomon H, Lewis E, Wang K, Stanislaus D
Birth Defects Res B Dev Reprod Toxicol
. 2016 Apr;
107(2):76-84.
PMID: 27038066
Embryo-fetal development (EFD) studies, typically in pregnant rats and rabbits, are conducted prior to enrolling females of reproductive age in clinical trials. Common rabbit strains used are the New Zealand...
9.
Posobiec L, Vidal J, Hughes-Earle A, Laffan S, Hart T
Birth Defects Res B Dev Reprod Toxicol
. 2015 Dec;
104(6):244-52.
PMID: 26626128
Dabrafenib (DAB), an inhibitor of BRAF kinase activity, is approved for metastatic melanoma with a BRAF V600E mutation. In support of pediatric cancer development, a nonclinical juvenile rat toxicity study...
10.
Posobiec L, Clark R, Bushdid P, Laffan S, Wang K, White T
Birth Defects Res B Dev Reprod Toxicol
. 2014 Jan;
98(6):445-58.
PMID: 24391093
Within 24 hr after oral administration of the antimalarial artesunate to rats on Day 10 or 11 postcoitum (pc), there is depletion of embryonic erythroblasts (EEbs), leading to embryo malformation...