Lorne M Golub
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Explore the profile of Lorne M Golub including associated specialties, affiliations and a list of published articles.
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60
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1292
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Recent Articles
1.
Golub L, Lee H, Bacigalupo J, Gu Y
Front Dent Med
. 2025 Feb;
5:1423401.
PMID: 39917713
No abstract available.
2.
Dai Q, Lee H, Giordano A, Chiang F, Walker S, Delgado-Ruiz R, et al.
Front Oral Health
. 2025 Jan;
5:1506616.
PMID: 39877403
Introduction: Previous studies have shown () esterase is a key mediator of dental composite biodegradation, which can contribute to recurrent caries. This study is to investigate the inhibitory effects of...
3.
Deng J, Golub L, Lee H, Bhatt H, Johnson F, Xu T, et al.
Sci Rep
. 2023 Sep;
13(1):15513.
PMID: 37726411
To assess resolving-like activity by a novel chemically-modified curcumin (CMC2.24) in a "two-hit" model of diabetes-associated periodontitis. Macrophages from rats were cultured in the presence/absence of either Lipopolysaccharide (LPS, 1st...
4.
Bhatt H, Golub L, Lee H, Kim J, Zimmerman T, Deng J, et al.
J Inflamm Res
. 2023 Mar;
16:779-792.
PMID: 36860795
Purpose: CMC2.24, a novel 4-(phenylaminocarbonyl)-chemically-modified-curcumin, is a pleiotropic MMP-Inhibitor of various inflammatory/collagenolytic diseases including periodontitis. This compound has demonstrated efficacy in host modulation therapy along with improved resolution of inflammation...
5.
Bhatt H, McClain S, Lee H, Zimmerman T, Deng J, Johnson F, et al.
J Exp Pharmacol
. 2022 Feb;
14:73-85.
PMID: 35173493
Purpose: CMC 2.24, a chemically modified curcumin, was developed as a novel, pleiotropic MMP-inhibitor to treat various inflammatory/collagenolytic diseases including periodontitis. To date, this compound has shown efficacy in vitro,...
6.
Deng J, Golub L, Lee H, Raja V, Johnson F, Kucine A, et al.
J Inflamm Res
. 2021 Oct;
14:5337-5347.
PMID: 34703272
Purpose: Clinically, it is challenging to manage diabetic patients with periodontitis. Biochemically, both involve a wide range of inflammatory/collagenolytic conditions which exacerbate each other in a "bi-directional manner." However, standard...
7.
Sorsa T, Sahni V, Buduneli N, Gupta S, Raisanen I, Golub L, et al.
Expert Rev Proteomics
. 2021 Sep;
18(8):707-717.
PMID: 34468272
Introduction: Active matrix metalloproteinase (aMMP)-8 utilized in point-of-care testing (POCT) is regarded as a potential biomarker for periodontal and peri-implant diseases. Various host and microbial factors eventually influence the expression,...
8.
Gu Y, Golub L, Lee H, Hou W, Ryan M
Am J Dent
. 2021 May;
34(2):97-100.
PMID: 33940667
Purpose: This pilot study assessed the periodontal status and biomarkers of systemic inflammation in acute coronary syndrome (ACS) patients. Methods: 15 ACS patients on statin (anti-cholesterol) therapy, were recruited into...
9.
Golub L, Raisanen I, Sorsa T, Preshaw P
Diagnostics (Basel)
. 2020 Dec;
10(12).
PMID: 33291429
Dental implants are widely utilized for the replacement of missing teeth and are increasingly being placed in patients with systemic diseases, as well as in those who are medically healthy....
10.
Deng J, Golub L, Lee H, Lin M, Bhatt H, Hong H, et al.
J Exp Pharmacol
. 2020 Feb;
12:47-60.
PMID: 32104105
Purpose: To determine the effect of a pleiotropic MMP-inhibitor, a novel chemically-modified curcumin 2.24 (CMC2.24), on the clinical and biological measures of naturally-occurring periodontitis in the beagle dog. Methods: Eight...