Lorna J Daniels
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Explore the profile of Lorna J Daniels including associated specialties, affiliations and a list of published articles.
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11
Citations
93
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Recent Articles
1.
Koutsifeli P, Daniels L, Neale J, Fong S, Varma U, Annandale M, et al.
bioRxiv
. 2024 Aug;
PMID: 39211188
Glycogen-autophagy ('glycophagy') is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycogen...
2.
Mellor K, Varma U, Koutsifeli P, Daniels L, Benson V, Annandale M, et al.
J Mol Cell Cardiol
. 2024 Mar;
189:83-89.
PMID: 38484473
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of...
3.
Daniels L, Kay D, Marjot T, Hodson L, Ray D
Am J Physiol Cell Physiol
. 2023 Aug;
325(5):C1158-C1177.
PMID: 37642240
Circadian rhythms are endogenous oscillations with approximately a 24-h period that allow organisms to anticipate the change between day and night. Disruptions that desynchronize or misalign circadian rhythms are associated...
4.
Nagarajan S, Cross E, Johnson E, Sanna F, Daniels L, Ray D, et al.
Physiol Rep
. 2022 Oct;
10(20):e15463.
PMID: 36301719
Pathological accumulation of intrahepatic triglyceride underpins the early stages of nonalcoholic fatty liver disease (NAFLD) and can progress to fibrosis, cirrhosis, and cancer of the liver. Studies in humans suggest...
5.
Koutsifeli P, Varma U, Daniels L, Annandale M, Li X, Neale J, et al.
J Biol Chem
. 2022 Jun;
298(7):102093.
PMID: 35654138
Autophagy is an essential cellular process involving degradation of superfluous or defective macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be a "bulk" degradation pathway, a...
6.
Daniels L, Annandale M, Koutsifeli P, Li X, Bussey C, van Hout I, et al.
Nutr Diabetes
. 2021 Feb;
11(1):8.
PMID: 33558456
Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology...
7.
Neale J, Pearson J, Thomas K, Tsuchimochi H, Hosoda H, Kojima M, et al.
Sci Rep
. 2020 Oct;
10(1):17556.
PMID: 33051469
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Neale J, Pearson J, Thomas K, Tsuchimochi H, Hosoda H, Kojima M, et al.
Sci Rep
. 2020 Aug;
10(1):13651.
PMID: 32788622
Type 2 diabetes is a prominent risk factor for peripheral artery disease (PAD). Yet, the mechanistic link between diabetes and PAD remains unclear. This study proposes that dysregulation of the...
9.
Daniels L, Varma U, Annandale M, Chan E, Mellor K, Delbridge L
Antioxid Redox Signal
. 2018 Nov;
31(6):472-486.
PMID: 30417655
Energy stress in the myocardium occurs in a variety of acute and chronic pathophysiological contexts, including ischemia, nutrient deprivation, and diabetic disease settings of substrate disturbance. Although the heart is...
10.
Daniels L, Wallace R, Nicholson O, Wilson G, McDonald F, Jones P, et al.
Cardiovasc Diabetol
. 2018 Jun;
17(1):89.
PMID: 29903013
Background: Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced cardiac performance. However, the effects...