Lorna C Gilligan
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Explore the profile of Lorna C Gilligan including associated specialties, affiliations and a list of published articles.
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32
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757
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Recent Articles
1.
Tomkins M, McDonnell T, Cussen L, Sagmeister M, Oestlund I, Shaheen F, et al.
J Clin Endocrinol Metab
. 2024 Oct;
PMID: 39382395
Context: 11-oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) in 11-oxygenated androgen biosynthesis,...
2.
Walchli-Popovic M, Monnerat S, Taylor A, Gilligan L, Schiffer L, Arlt W, et al.
Front Endocrinol (Lausanne)
. 2024 Sep;
15:1435698.
PMID: 39324125
Introduction: Chronic low-grade inflammation might contribute to hyperandrogenemia and metabolic complications in polycystic ovary syndrome (PCOS). The proinflammatory cytokine interleukin (IL)-1 stimulates androgen production from ovarian cells, whereas blockade of...
3.
Elhassan Y, Appenzeller S, Landwehr L, Lippert J, Popat D, Gilligan L, et al.
Eur J Endocrinol
. 2024 Aug;
191(3):334-344.
PMID: 39171930
Background: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing's syndrome. Individuals with PBMAH and glucose-dependent insulinotropic polypeptide (GIP)-dependent Cushing's syndrome due to ectopic expression of the...
4.
Timmerman S, Mullen N, Taylor A, Gilligan L, Pyle M, Shrestha T, et al.
bioRxiv
. 2024 May;
PMID: 38766205
Introduction: Aldosterone-producing adenoma (APA) is the most common cause of endocrine-related hypertension but surgery is not always feasible. Current medical interventions are associated with significant side effects and poor patient...
5.
Schiffer L, Oestlund I, Snoep J, Gilligan L, Taylor A, Sinclair A, et al.
FASEB J
. 2024 Mar;
38(7):e23574.
PMID: 38551804
Aldo-keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both classic and 11-oxygenated androgens. In adipose tissue, AKR1C3 is co-expressed with 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which...
6.
Sampson O, Jay C, Adland E, Csala A, Lim N, Ebbrecht S, et al.
Front Immunol
. 2024 Mar;
15:1329805.
PMID: 38481993
mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Type I interferon (IFN-I) is...
7.
Prete A, Lang K, Pavlov D, Rhayem Y, Sitch A, Franke A, et al.
J Steroid Biochem Mol Biol
. 2023 Dec;
237:106445.
PMID: 38104729
Primary aldosteronism (PA) causes 5-10% of hypertension cases, but only a minority of patients are currently diagnosed and treated because of a complex, stepwise, and partly invasive workup. We tested...
8.
Dineen R, Martin-Grace J, Ahmed K, Taylor A, Shaheen F, Schiffer L, et al.
J Clin Endocrinol Metab
. 2023 Jun;
108(12):3178-3189.
PMID: 37339332
Background: Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We hypothesize...
9.
Bentley C, Hazeldine J, Bravo L, Taylor A, Gilligan L, Shaheen F, et al.
Eur J Endocrinol
. 2023 Feb;
188(3).
PMID: 36809311
Objective: Trauma-induced steroid changes have been studied post-hospital admission, resulting in a lack of understanding of the speed and extent of the immediate endocrine response to injury. The Golden Hour...
10.
Schiffer L, Shaheen F, Gilligan L, Storbeck K, Hawley J, Keevil B, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2022 Aug;
1209:123413.
PMID: 35988498
Background: Multi-steroid profiling is a powerful analytical tool that simultaneously quantifies steroids from different biosynthetic pathways. Here we present an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay for the...