Lorenzo Silengo
Overview
Explore the profile of Lorenzo Silengo including associated specialties, affiliations and a list of published articles.
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Articles
84
Citations
2960
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Recent Articles
1.
Maccagno M, Tapparo M, Saccu G, Rumiano L, Kholia S, Silengo L, et al.
Med Sci (Basel)
. 2024 Sep;
12(3).
PMID: 39311156
The rise in biological therapies has revolutionized oncology, with immunotherapy leading the charge through breakthroughs such as CAR-T cell therapy for melanoma and B-ALL. Modified bispecific antibodies and CAR-T cells...
2.
Sorge M, Savore G, Gallo A, Acquarone D, Sbroggio M, Velasco S, et al.
EMBO Mol Med
. 2024 Sep;
16(10):2450-2484.
PMID: 39271959
Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective approaches to protect the heart. A physiologic level of ROS is produced in the heart by fatty acid...
3.
Ferro A, Saccu G, Mattivi S, Gaido A, Herrera Sanchez M, Haque S, et al.
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540698
In recent years, EVs have emerged as promising vehicles for coding and non-coding RNAs (ncRNAs), which have demonstrated remarkable potential as biomarkers for various diseases, including chronic liver diseases (CLDs)....
4.
Tapparo M, Saccu G, Pasquino C, Fonsato V, Medana C, Schiavo V, et al.
Front Cell Dev Biol
. 2024 Feb;
12:1352013.
PMID: 38389704
The lack of functional hepatocytes poses a significant challenge for drug safety testing and therapeutic applications due to the inability of mature hepatocytes to expand and their tendency to lose...
5.
Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, et al.
J Cell Sci
. 2023 Oct;
136(20).
PMID: 37855734
No abstract available.
6.
Cernigliaro V, Peluso R, Zedda B, Silengo L, Tolosano E, Pellicano R, et al.
Cells
. 2020 Feb;
9(2).
PMID: 32046114
Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of...
7.
Famulari E, Navarro-Tableros V, Herrera Sanchez M, Bortolussi G, Gai M, Conti L, et al.
Sci Rep
. 2020 Jan;
10(1):887.
PMID: 31965023
Crigler Najjar Syndrome type I (CNSI) is a rare recessive disorder caused by mutations in the Ugt1a1 gene. There is no permanent cure except for liver transplantation, and current therapies...
8.
Spada M, Porta F, Righi D, Gazzera C, Tandoi F, Ferrero I, et al.
Stem Cell Rev Rep
. 2019 Dec;
16(1):186-197.
PMID: 31792768
Previous studies have shown that human liver stem-like cells (HLSCs) may undergo differentiation in vitro into urea producing hepatocytes and in vivo may sustain liver function in models of experimentally...
9.
De Chiara L, Famulari E, Fagoonee S, van Daalen S, Buttiglieri S, Revelli A, et al.
Stem Cells Int
. 2018 Sep;
2018:4910304.
PMID: 30250488
Mesenchymal stem cells hold great promise for regenerative medicine as they can be easily isolated from different sources such as adipose tissue, bone marrow, and umbilical cord blood. Spontaneously arising...
10.
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, et al.
Cell Death Differ
. 2017 Dec;
25(3):573-588.
PMID: 29229999
Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species...