Lorena Simon-Gracia
Overview
Explore the profile of Lorena Simon-Gracia including associated specialties, affiliations and a list of published articles.
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25
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1228
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Recent Articles
1.
Sidorenko V, Scodeller P, Uustare A, Ogibalov I, Tasa A, Tshubrik O, et al.
Sci Rep
. 2024 Jul;
14(1):17513.
PMID: 39080306
Cancer treatment with vascular disrupting agents (VDAs) causes rapid and extensive necrosis in solid tumors. However, these agents fall short in eliminating all malignant cells, ultimately leading to tumor regrowth....
2.
Simon-Gracia L, Sidorenko V, Uustare A, Ogibalov I, Tasa A, Tshubrik O, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(31):17155-17164.
PMID: 38505658
Novel anticancer compounds and their precision delivery systems are actively developed to create potent and well-tolerated anticancer therapeutics. Here, we report the synthesis of a novel anthracycline, Utorubicin (UTO), and...
3.
Marchetti L, Simon-Gracia L, Lico C, Mancuso M, Baschieri S, Santi L, et al.
Nanomaterials (Basel)
. 2023 Apr;
13(8).
PMID: 37111013
Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse...
4.
Simon-Gracia L, Scodeller P, Fisher W, Sidorenko V, Steffes V, Ewert K, et al.
ACS Appl Mater Interfaces
. 2022 Dec;
14(51):56613-56622.
PMID: 36521233
Novel approaches are required to address the urgent need to develop lipid-based carriers of paclitaxel (PTX) and other hydrophobic drugs for cancer chemotherapy. Carriers based on cationic liposomes (CLs) with...
5.
Simonetti B, Daly J, Simon-Gracia L, Klein K, Weeratunga S, Anton-Plagaro C, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(25):e2201980119.
PMID: 35696571
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the -Golgi...
6.
Simon-Gracia L, Loisel S, Sidorenko V, Scodeller P, Parizot C, Savier E, et al.
Mol Pharm
. 2022 Feb;
19(3):895-903.
PMID: 35113575
Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults. The disease is characterized by the accumulation of tumoral B cells resulting from a defect of apoptosis....
7.
Simon-Gracia L, Kiisholts K, Petrikaite V, Tobi A, Saare M, Lingasamy P, et al.
Nanomaterials (Basel)
. 2021 Dec;
11(12).
PMID: 34947606
The current diagnostic and therapeutic strategies for endometriosis are limited. Although endometriosis is a benign condition, some of its traits, such as increased cell invasion, migration, tissue inflammation, and angiogenesis...
8.
Savier E, Simon-Gracia L, Charlotte F, Tuffery P, Teesalu T, Scatton O, et al.
Pharmaceutics
. 2021 Oct;
13(10).
PMID: 34683924
Background: The interfering peptides that block protein-protein interactions have been receiving increasing attention as potential therapeutic tools. Methods: We measured the internalization and biological effect of four bi-functional tumor-penetrating and...
9.
Ewert K, Scodeller P, Simon-Gracia L, Steffes V, Wonder E, Teesalu T, et al.
Pharmaceutics
. 2021 Sep;
13(9).
PMID: 34575441
Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA (siRNA), have...
10.
Simon-Gracia L, Sidorenko V, Uustare A, Ogibalov I, Tasa A, Tshubrik O, et al.
Angew Chem Int Ed Engl
. 2021 Apr;
60(31):17018-17027.
PMID: 33908690
Novel anticancer compounds and their precision delivery systems are actively developed to create potent and well-tolerated anticancer therapeutics. Here, we report the synthesis of a novel anthracycline, Utorubicin (UTO), and...