Lorena Magraner-Pardo
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Explore the profile of Lorena Magraner-Pardo including associated specialties, affiliations and a list of published articles.
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12
Citations
271
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Recent Articles
1.
Seed G, Beije N, Yuan W, Bertan C, Goodall J, Lundberg A, et al.
Cancer Cell
. 2024 Nov;
42(12):2113-2123.e4.
PMID: 39577422
PARP inhibition (PARPi) has anti-tumor activity against castration-resistant prostate cancer (CRPC) with homologous recombination repair (HRR) defects. However, mechanisms underlying PARPi resistance are not fully understood. While acquired mutations restoring...
2.
Mur P, Viana-Errasti J, Garcia-Mulero S, Magraner-Pardo L, Munoz I, Pons T, et al.
Genome Med
. 2023 Oct;
15(1):85.
PMID: 37848928
Background: Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a...
3.
Reyes-Gonzalez J, Barajas-Olmos F, Garcia-Ortiz H, Magraner-Pardo L, Pons T, Moreno S, et al.
Neuro Oncol
. 2022 Jul;
25(2):303-314.
PMID: 35802478
Background: Glioblastoma is the most common and devastating primary brain cancer. Radiotherapy is standard of care; however, it is associated with brain radiation toxicity (BRT). This study used a multi-omics...
4.
Magraner-Pardo L, Gobelli D, de la Fuente M, Pons T, Simarro M
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34768773
The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including mRNA stability and translation. Accumulated studies have...
5.
Mur P, Magraner-Pardo L, Garcia-Mulero S, Diez-Villanueva A, Del Valle J, Ezquerro E, et al.
Eur J Hum Genet
. 2021 Jul;
30(4):485-489.
PMID: 34285382
Germline variants that affect the proofreading activity of polymerases epsilon (POLE) and delta (POLD1) predispose to colorectal adenomas and carcinomas, among other cancers. All cancer-associated pathogenic variants reported to date...
6.
Magraner-Pardo L, Laskowski R, Pons T, Thornton J
Sci Rep
. 2021 Jul;
11(1):14268.
PMID: 34253785
DNA-Damage Response (DDR) proteins are crucial for maintaining the integrity of the genome by identifying and repairing errors in DNA. Variants affecting their function can have severe consequences since failure...
7.
Mur P, Garcia-Mulero S, Del Valle J, Magraner-Pardo L, Vidal A, Pineda M, et al.
Genet Med
. 2020 Aug;
22(12):2089-2100.
PMID: 32792570
Purpose: Germline pathogenic variants in the exonuclease domain (ED) of polymerases POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC), endometrial tumors, and other malignancies, and exhibit increased mutation...
8.
Piccolo P, Sabatino V, Mithbaokar P, Polishchuck E, Law S, Magraner-Pardo L, et al.
Mol Genet Metab Rep
. 2019 Sep;
21:100504.
PMID: 31516831
Geleophysic dysplasia (GPHYSD1, MIM231050; GPHYSD2, MIM614185; GPHYSD3, MIM617809) is an autosomal disorder characterized by short-limb dwarfism, brachydactyly, cardiac valvular disease, and laryngotracheal stenosis. Mutations in , , and genes are...
9.
Castro E, Romero-Laorden N, Del Pozo A, Lozano R, Medina A, Puente J, et al.
J Clin Oncol
. 2019 Jan;
37(6):490-503.
PMID: 30625039
Purpose: Germline mutations in DNA damage repair (DDR) genes are identified in a significant proportion of patients with metastatic prostate cancer, but the clinical implications of these genes remain unclear....
10.
Usach I, Talens-Visconti R, Magraner-Pardo L, Peris J
Food Chem Toxicol
. 2015 Mar;
80:80-84.
PMID: 25765751
One of the major sources of flavonoids for humans are citrus fruits, hesperidin being the predominant flavonoid. Hesperetin (HSP), the aglycon of hesperidin, has been reported to provide health benefits...