Lorela Paco
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Explore the profile of Lorela Paco including associated specialties, affiliations and a list of published articles.
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5
Citations
43
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0
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Recent Articles
1.
Paco L, Hackett J, Atkins W
J Inorg Biochem
. 2023 Apr;
244:112211.
PMID: 37080138
Cytochrome P450 3A4 (CYP3A4) metabolizes a wide range of drugs and toxins. Interactions of CYP3A4 with ligands are difficult to predict due to promiscuity and conformational flexibility. To better understand...
2.
Scian M, Paco L, Murphree T, Shireman L, Atkins W
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830698
High concentrations of electrophilic lipid alkenals formed during oxidative stress are implicated in cytotoxicity and disease. However, low concentrations of alkenals are required to induce antioxidative stress responses. An established...
3.
Paco L, Zarate-Perez F, Clouser A, Atkins W, Hackett J
Biochemistry
. 2020 Aug;
59(33):2999-3009.
PMID: 32786398
Aromatase (CYP19A1) catalyzes the synthesis of estrogens from androgens and is an invaluable target of pharmacotherapy for estrogen-dependent cancers. CYP19A1 is also one of the most primordial human CYPs and,...
4.
McDonald M, Ray S, Amorosi C, Sitko K, Kowalski J, Paco L, et al.
Drug Metab Dispos
. 2017 Oct;
45(12):1364-1371.
PMID: 29018033
CYP4Z1 is an "orphan" cytochrome P450 (P450) enzyme that has provoked interest because of its hypothesized role in breast cancer through formation of the signaling molecule 20-hydroxyeicosatetraenoic acid (20-HETE). We...
5.
McClary W, Sumida J, Scian M, Paco L, Atkins W
Biochemistry
. 2016 Nov;
55(45):6258-6268.
PMID: 27782404
Cytochrome P4503A4 (CYP3A4) is a peripheral membrane protein that plays a major role in enzymatic detoxification of many drugs and toxins. CYP3A4 has an integral membrane N-terminal helix and a...