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Loredana Le Pera

Explore the profile of Loredana Le Pera including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 255
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Recent Articles
1.
Pacelli C, Rossi A, Milella M, Colombo T, Le Pera L
Int J Mol Sci . 2023 Oct; 24(19). PMID: 37834310
Precision medicine in oncology has made significant progress in recent years by approving drugs that target specific genetic mutations. However, many cancer driver genes remain challenging to pharmacologically target ("undruggable")....
2.
Piscopo P, Manzini V, Rivabene R, Crestini A, Le Pera L, Pizzi E, et al.
Int J Mol Sci . 2022 Nov; 23(21). PMID: 36362022
The most frequently used biomarkers to support the diagnosis of Alzheimer’s Disease (AD) are Aβ42, total-Tau, and phospho-tau protein levels in CSF. Moreover, magnetic resonance imaging is used to assess...
3.
Bazzichetto C, Milella M, Zampiva I, Simionato F, Amoreo C, Buglioni S, et al.
Biomedicines . 2022 Oct; 10(10). PMID: 36289899
Among soluble actors that have emerged as druggable factors, the chemokine interleukin-8 (IL-8) has emerged as a possible determinant of response to immunotherapy and targeted treatment in several cancer types;...
4.
Pisano A, Le Pera L, Carletti R, Cerbelli B, Pignataro M, Pernazza A, et al.
Microcirculation . 2022 Oct; 29(8):e12790. PMID: 36198058
Objective: Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms...
5.
Bossa C, Branchi I, Caccia B, Cisbani E, Daniele C, DAvenio G, et al.
Ann Ist Super Sanita . 2022 Sep; 58(3):151-153. PMID: 36128961
No abstract available.
6.
Caudai C, Galizia A, Geraci F, Le Pera L, Morea V, Salerno E, et al.
Comput Struct Biotechnol J . 2021 Nov; 19:5762-5790. PMID: 34765093
We review the current applications of artificial intelligence (AI) in functional genomics. The recent explosion of AI follows the remarkable achievements made possible by "deep learning", along with a burst...
7.
Abiusi E, Infante P, Cagnoli C, Lospinoso Severini L, Pane M, Coratti G, et al.
Elife . 2021 Sep; 10. PMID: 34542403
Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. The phenotype ranges from very severe to very mild forms. All patients...
8.
Gurwitz K, Singh Gaur P, Bellis L, Larcombe L, Alloza E, Balint B, et al.
PLoS Comput Biol . 2020 Jul; 16(7):e1007976. PMID: 32702016
ELIXIR is a pan-European intergovernmental organisation for life science that aims to coordinate bioinformatics resources in a single infrastructure across Europe; bioinformatics training is central to its strategy, which aims...
9.
Mathlin J, Le Pera L, Colombo T
Int J Mol Sci . 2020 Jul; 21(13). PMID: 32630140
In the past few years, thorough investigation of chemical modifications operated in the cells on ribonucleic acid (RNA) molecules is gaining momentum. This new field of research has been dubbed...
10.
Garcia L, Batut B, Burke M, Kuzak M, Psomopoulos F, Arcila R, et al.
PLoS Comput Biol . 2020 May; 16(5):e1007854. PMID: 32437350
Everything we do today is becoming more and more reliant on the use of computers. The field of biology is no exception; but most biologists receive little or no formal...