Lode De Cauwer
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Explore the profile of Lode De Cauwer including associated specialties, affiliations and a list of published articles.
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15
Citations
283
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0
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Recent Articles
1.
Desmet S, Thommis J, Vanderhaeghen T, Vandenboorn E, Clarisse D, Li Y, et al.
Mol Metab
. 2024 Apr;
84:101938.
PMID: 38631478
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function...
2.
Bougarne N, Mylka V, Ratman D, Beck I, Thommis J, De Cauwer L, et al.
Front Immunol
. 2019 Aug;
10:1769.
PMID: 31447832
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such...
3.
Mylka V, Deckers J, Ratman D, De Cauwer L, Thommis J, De Rycke R, et al.
Autophagy
. 2018 Sep;
14(12):2049-2064.
PMID: 30215534
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid...
4.
Cauwels A, Van Lint S, Garcin G, Bultinck J, Paul F, Gerlo S, et al.
Oncoimmunology
. 2018 Feb;
7(3):e1398876.
PMID: 29399401
Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized...
5.
Deckers J, Bougarne N, Mylka V, Desmet S, Luypaert A, Devos M, et al.
J Invest Dermatol
. 2017 Dec;
138(6):1360-1370.
PMID: 29288652
Children with atopic dermatitis show an increased risk to develop asthma later in life, a phenomenon referred to as "atopic march," which emphasizes the need for secondary prevention therapies. This...
6.
Baetens D, Guran T, Mendonca B, Gomes N, De Cauwer L, Peelman F, et al.
Genet Med
. 2017 Dec;
20(7):717-727.
PMID: 29261182
Purpose: Disorders or differences of sex development (DSDs) are rare congenital conditions characterized by atypical sex development. Despite advances in genomic technologies, the molecular cause remains unknown in 50% of...
7.
Mori R, Wauman J, Icardi L, Van der Heyden J, De Cauwer L, Peelman F, et al.
Sci Rep
. 2017 Nov;
7(1):15919.
PMID: 29162862
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series...
8.
Zielinska K, De Cauwer L, Knoops S, Van der Molen K, Sneyers A, Thommis J, et al.
Front Immunol
. 2017 Oct;
8:1199.
PMID: 29033931
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical...
9.
Petta I, Bougarne N, Vandewalle J, Dejager L, Vandevyver S, Ballegeer M, et al.
Sci Rep
. 2017 Aug;
7(1):8941.
PMID: 28827617
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel...
10.
Dendoncker K, Timmermans S, Van Looveren K, De Cauwer L, De Bosscher K, Libert C
PLoS One
. 2017 Jul;
12(7):e0181101.
PMID: 28686666
Glucocorticoid resistance (GCR), i.e. unresponsiveness to the beneficial anti-inflammatory activities of the glucocorticoid receptor (GR), poses a serious problem in the treatment of inflammatory diseases. One possible solution to try...