Lo-I Cheng
Overview
Explore the profile of Lo-I Cheng including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
3
Citations
52
Followers
0
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Recent Articles
1.
Arnaoutova I, Aratyn-Schaus Y, Zhang L, Packer M, Chen H, Lee C, et al.
Nat Commun
. 2024 Nov;
15(1):9729.
PMID: 39523369
Glycogen storage disease type-Ia patients, deficient in the G6PC1 gene encoding glucose-6-phosphatase-α, lack blood glucose control, resulting in life-threatening hypoglycemia. Here we show our humanized mouse model, huR83C, carrying the...
2.
Packer M, Chowdhary V, Lung G, Cheng L, Aratyn-Schaus Y, Leboeuf D, et al.
Mol Ther
. 2022 Feb;
30(4):1396-1406.
PMID: 35121111
Alpha-1 antitrypsin deficiency (AATD) is a rare autosomal codominant disease caused by mutations within the SERPINA1 gene. The most prevalent variant in patients is PiZ SERPINA1, containing a single G...
3.
Chu S, Packer M, Rees H, Lam D, Yu Y, Marshall J, et al.
CRISPR J
. 2021 Apr;
4(2):169-177.
PMID: 33876959
Base editors are fusions of a deaminase and CRISPR-Cas ribonucleoprotein that allow programmable installment of transition mutations without double-strand DNA break intermediates. The breadth of potential base editing targets is...