Lisa Perruzza
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Explore the profile of Lisa Perruzza including associated specialties, affiliations and a list of published articles.
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20
Citations
420
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Recent Articles
1.
Tejedor Vaquero S, Neuman H, Comerma L, Marcos-Fa X, Corral-Vazquez C, Uzzan M, et al.
J Exp Med
. 2024 Nov;
221(12).
PMID: 39560666
The human gut includes plasma cells (PCs) expressing immunoglobulin A1 (IgA1) or IgA2, two structurally distinct IgA subclasses with elusive regulation, function, and reactivity. We show here that intestinal IgA1+...
2.
Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses
Rexhepaj M, Asarnow D, Perruzza L, Park Y, Guarino B, Mccallum M, et al.
Immunity
. 2024 Nov;
57(12):2914-2927.e7.
PMID: 39488210
Porcine delta-coronavirus (PDCoV) spillovers were recently detected in febrile children, underscoring the recurrent zoonoses of divergent CoVs. To date, no vaccines or specific therapeutics are approved for use in humans...
3.
Perruzza L, Heckmann J, Rezzonico Jost T, Raneri M, Guglielmetti S, Gargari G, et al.
Nat Commun
. 2024 Oct;
15(1):8623.
PMID: 39366940
Malnutrition is linked to 45% of global childhood mortality, however, the impact of maternal malnutrition on the child's health remains elusive. Previous studies suggested that maternal malnutrition does not affect...
4.
Perruzza L, Rezzonico Jost T, Raneri M, Gargari G, Palatella M, De Ponte Conti B, et al.
Cell Rep Med
. 2024 Jul;
5(7):101639.
PMID: 38959887
Environmental enteric dysfunction (EED) is a condition associated with malnutrition that can progress to malabsorption and villous atrophy. Severe EED results in linear growth stunting, slowed neurocognitive development, and unresponsiveness...
5.
Rexhepaj M, Park Y, Perruzza L, Asarnow D, Mccallum M, Culap K, et al.
bioRxiv
. 2024 Apr;
PMID: 38617231
Porcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses. To date, no vaccines or specific therapeutics are approved for...
6.
Perruzza L, Zagaglia C, Vitiello L, Sarshar M, Strati F, Pasqua M, et al.
Microbiol Spectr
. 2023 Oct;
11(6):e0077523.
PMID: 37795996
In this paper, we demonstrated that apyrase is released within the host cell cytoplasm during infection to target the intracellular ATP pool. By degrading intracellular ATP, apyrase contributes to prevent...
7.
Perruzza L, Strati F, Raneri M, Li H, Gargari G, Rezzonico-Jost T, et al.
Cell Rep
. 2022 Jul;
40(3):111112.
PMID: 35858559
Secretory immunoglobulin A (SIgA) interaction with commensal bacteria conditions microbiota composition and function. However, mechanisms regulating reciprocal control of microbiota and SIgA are not defined. Bacteria-derived adenosine triphosphate (ATP) limits...
8.
Jester B, Zhao H, Gewe M, Adame T, Perruzza L, Bolick D, et al.
Nat Biotechnol
. 2022 Apr;
40(6):974.
PMID: 35440781
No abstract available.
9.
Jester B, Zhao H, Gewe M, Adame T, Perruzza L, Bolick D, et al.
Nat Biotechnol
. 2022 Mar;
40(6):956-964.
PMID: 35314813
The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a biomanufacturing platform has been limited by a lack of genetic tools. Here we report genetic engineering methods for...
10.
Romagnani A, Rottoli E, Mazza E, Rezzonico-Jost T, De Ponte Conti B, Proietti M, et al.
Cancer Res
. 2020 Jul;
80(18):3906-3919.
PMID: 32699136
Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune system either directly or after hydrolysis to adenosine. Although eATP is virtually absent in the...