Liqun Xi
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Explore the profile of Liqun Xi including associated specialties, affiliations and a list of published articles.
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15
Citations
678
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Recent Articles
1.
Voong L, Xi L, Wang J, Wang X
Trends Genet
. 2017 Jul;
33(8):495-507.
PMID: 28693826
Nucleosomes regulate the transcription output of the genome by occluding the underlying DNA sequences from DNA-binding proteins that must act on it. Knowledge of the precise locations of nucleosomes in...
2.
Voong L, Xi L, Sebeson A, Xiong B, Wang J, Wang X
Cell
. 2016 Nov;
167(6):1555-1570.e15.
PMID: 27889238
Nucleosome organization influences gene activity by controlling DNA accessibility to transcription machinery. Here, we develop a chemical biology approach to determine mammalian nucleosome positions genome-wide. We uncovered surprising features of...
3.
Sebeson A, Xi L, Zhang Q, Sigmund A, Wang J, Widom J, et al.
PLoS One
. 2015 May;
10(5):e0127214.
PMID: 25992972
The binding sequence for any transcription factor can be found millions of times within a genome, yet only a small fraction of these sequences encode functional transcription factor binding sites....
4.
Small E, Xi L, Wang J, Widom J, Licht J
Proc Natl Acad Sci U S A
. 2014 Jun;
111(24):E2462-71.
PMID: 24889621
Nucleosomes, the basic unit of chromatin, have a critical role in the control of gene expression. Nucleosome positions have generally been determined by examining bulk populations of cells and then...
5.
Xi L, Brogaard K, Zhang Q, Lindsay B, Widom J, Wang J
J Am Stat Assoc
. 2014 Mar;
109(505):48-62.
PMID: 24678133
Nucleosome is the fundamental packing unit of DNA in eukaryotic cells, and its positioning plays a critical role in regulation of gene expression and chromosome functions. Using a recently developed...
6.
Moyle-Heyrman G, Zaichuk T, Xi L, Zhang Q, Uhlenbeck O, Holmgren R, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(50):20158-63.
PMID: 24277842
Using a recently developed chemical approach, we have generated a genome-wide map of nucleosomes in vivo in Schizosaccharomyces pombe (S. pombe) at base pair resolution. The shorter linker length previously...
7.
Nalabothula N, Xi L, Bhattacharyya S, Widom J, Wang J, Reeve J, et al.
BMC Genomics
. 2013 Jun;
14:391.
PMID: 23758892
Background: Histone wrapping of DNA into nucleosomes almost certainly evolved in the Archaea, and predates Eukaryotes. In Eukaryotes, nucleosome positioning plays a central role in regulating gene expression and is...
8.
Yigit E, Zhang Q, Xi L, Grilley D, Widom J, Wang J, et al.
Nucleic Acids Res
. 2013 Feb;
41(7):e87.
PMID: 23413004
We report a target enrichment method to map nucleosomes of large genomes at unprecedented coverage and resolution by deeply sequencing locus-specific mononucleosomal DNA enriched via hybridization with bacterial artificial chromosomes....
9.
Brogaard K, Xi L, Wang J, Widom J
Methods Enzymol
. 2012 Aug;
513:315-34.
PMID: 22929776
Most eukaryotic DNA exists in DNA-protein complexes known as nucleosomes. The exact locations of nucleosomes along the genome play a critical role in chromosome functions and gene regulation. However, the...
10.
Brogaard K, Xi L, Wang J, Widom J
Nature
. 2012 Jun;
486(7404):496-501.
PMID: 22722846
The exact positions of nucleosomes along genomic DNA can influence many aspects of chromosome function. However, existing methods for mapping nucleosomes do not provide the necessary single-base-pair accuracy to determine...