Lindsay S Roberts
Overview
Explore the profile of Lindsay S Roberts including associated specialties, affiliations and a list of published articles.
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12
Citations
549
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Recent Articles
1.
Sponton C, Hosono T, Taura J, Jedrychowski M, Yoneshiro T, Wang Q, et al.
EMBO Rep
. 2020 Jul;
21(9):e49828.
PMID: 32672883
While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose...
2.
Wallace M, Green C, Roberts L, Lee Y, McCarville J, Sanchez-Gurmaches J, et al.
Nat Chem Biol
. 2018 Oct;
14(11):1021-1031.
PMID: 30327559
Fatty acid synthase (FASN) predominantly generates straight-chain fatty acids using acetyl-CoA as the initiating substrate. However, monomethyl branched-chain fatty acids (mmBCFAs) are also present in mammals but are thought to...
3.
Tam A, Roberts L, Chandra V, Rivera I, Nomura D, Forbes D, et al.
Dev Cell
. 2018 Aug;
46(3):327-343.e7.
PMID: 30086303
The unfolded protein response (UPR) is induced by proteotoxic stress of the endoplasmic reticulum (ER). Here we report that ATF6, a major mammalian UPR sensor, is also activated by specific...
4.
Roberts L, Yan P, Bateman L, Nomura D
ACS Chem Biol
. 2017 Mar;
12(4):1133-1140.
PMID: 28248089
Triple-negative breast cancers (TNBCs) are estrogen receptor, progesterone receptor, and HER2 receptor-negative subtypes of breast cancers that show the worst prognoses and lack targeted therapies. Here, we have coupled the...
5.
Kohnz R, Roberts L, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, et al.
ACS Chem Biol
. 2016 Jul;
11(8):2131-9.
PMID: 27380425
Many mechanisms have been proposed for how heightened aerobic glycolytic metabolism fuels cancer pathogenicity, but there are still many unexplored pathways. Here, we have performed metabolomic profiling to map glucose...
6.
Thompson A, Bruss M, Price J, Khambatta C, Holmes W, Colangelo M, et al.
Aging Cell
. 2015 Nov;
15(1):118-27.
PMID: 26541492
Combating the social and economic consequences of a growing elderly population will require the identification of interventions that slow the development of age-related diseases. Preserved cellular homeostasis and delayed aging...
7.
Benjamin D, Cozzo A, Ji X, Roberts L, Louie S, Mulvihill M, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(37):14912-7.
PMID: 23980144
Aberrant lipid metabolism is an established hallmark of cancer cells. In particular, ether lipid levels have been shown to be elevated in tumors, but their specific function in cancer remains...
8.
Louie S, Roberts L, Mulvihill M, Luo K, Nomura D
Biochim Biophys Acta
. 2013 Jul;
1831(10):1566-72.
PMID: 23872477
De novo lipogenesis is considered the primary source of fatty acids for lipid synthesis in cancer cells, even in the presence of exogenous fatty acids. Here, we have used an...
9.
Louie S, Roberts L, Nomura D
Biochim Biophys Acta
. 2013 Mar;
1831(10):1499-508.
PMID: 23470257
The incidence of obesity in US adults has been steadily increasing over the past few decades. Many comorbidities associated with obesity have been well-established such as type 2 diabetes and...
10.
Price J, Khambatta C, Li K, Bruss M, Shankaran M, Dalidd M, et al.
Mol Cell Proteomics
. 2012 Sep;
11(12):1801-14.
PMID: 22984287
Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness....