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Lindsay M Thomson

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Recent Articles
1.
Davidson J, Iguidbashian J, Khailova L, Lehmann T, Suarez-Pierre A, Thomson L, et al.
Transl Res . 2025 Jan; 277:64-74. PMID: 39827912
The organ-level molecular response to cardiac surgery with cardiopulmonary bypass (CPB) remains inadequately understood and may be heterogeneous. Here, we measured organ-specific gene expression in a piglet model of CPB...
2.
Thomson L, Niemiec S, Mancuso C, Khailova L, Ali E, Syed A, et al.
J Pediatr . 2024 Sep; 276:114322. PMID: 39306320
This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not...
3.
Wolfe K, Thomson L, Niemiec S, Mancuso C, Khailova L, Frank B, et al.
JAMA Pediatr . 2024 Aug; 178(10):1072-1074. PMID: 39102258
No abstract available.
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Thomson L, Mancuso C, Wolfe K, Khailova L, Niemiec S, Ali E, et al.
Front Pediatr . 2023 Dec; 11:1308700. PMID: 38143535
Introduction: Children with single ventricle heart disease (SVHD) experience significant morbidity across systems and time, with 70% of patients experiencing acute kidney injury, 33% neurodevelopmental impairment, 14% growth failure, and...
6.
Perry D, Thomson L, Pigula F, Polizzotti B, DiNardo J, Nedder A, et al.
Acta Anaesthesiol Scand . 2018 Aug; 63(1):93-100. PMID: 30109703
Background: Hyperoxemia (arterial oxygen tension >100 mm Hg) may occur in critically ill patients and have effects on mixed venous saturation (SvO ) and on Fick-based estimates of cardiac output...
7.
Perry D, Salvin J, Romfh P, Chen P, Krishnamurthy K, Thomson L, et al.
Sci Transl Med . 2017 Sep; 9(408). PMID: 28931652
Assessing the adequacy of oxygen delivery to tissues is vital, particularly in the fields of intensive care medicine and surgery. As oxygen delivery to a cell becomes deficient, changes in...
8.
Black K, Lock A, Thomson L, Cole A, Tang X, Polizzotti B, et al.
Pharm Res . 2017 Jul; 34(10):2156-2162. PMID: 28685297
Purpose: Low oxygen levels, or hypoxemia, is a common cause of morbidity and mortality in critically ill patients. Hypoxemia is typically addressed by increasing the fraction of inspired oxygen, the...
9.
Thomson L, Polizzotti B, McGowan F, Kheir J
J Vis Exp . 2014 Jun; (87). PMID: 24894333
Gas-filled microbubbles have been developed as ultrasound contrast and drug delivery agents. Microbubbles can be produced by processing surfactants using sonication, mechanical agitation, microfluidic devices, or homogenization. Recently, lipid-based oxygen...
10.
Polizzotti B, Thomson L, OConnell D, McGowan F, Kheir J
J Biomed Mater Res B Appl Biomater . 2014 Jan; 102(6):1148-56. PMID: 24425069
Tissue hypoxia is a final common pathway that leads to cellular injury and death in a number of critical illnesses. Intravenous injections of self-assembling, lipid-based oxygen microbubbles (LOMs) can be...